Evidence for the coupling of bone formation to bone resorption in vitro

G. A. Howard, B. L. Bottemiller, D. J. Baylink

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


An in vitro organ culture system of embryonic chick tibiae was used to examine bone formation and bone resorption under conditions of stimulation with 10-12 M parathyroid extract. The bones were cultured in a serum-free medium to alleviate any potential interference by serum growth factors. Evidence is presented showing that this bone culture system responds to parathyroid extract with an increase in both bone resorption and bone formation. Although initially there was a decrease in formation, this was followed after 12-16 h by an increase in formation which was correlated with resorption (r = .96, p < .05). These results suggest that the increase in formation was some consequence of the increase in resorption, and as such are consistent with the interpretation that coupling can occur in vitro.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalMetabolic Bone Disease and Related Research
Issue number2
StatePublished - 1980
Externally publishedYes


  • Bone formation
  • Bone metabolism
  • Bone resorption
  • Coupling
  • Mineralized tissue
  • Skeletal metabolism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery


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