Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

Bernard Conrad, Eckhart Weidmann, Giuliana Trucco, William A. Rudert, Roubik Behboo, Camillo Ricordi, Horacio Rodriquez-Rilo, David Finegold, Massimo Trucco

Research output: Contribution to journalArticle

302 Scopus citations

Abstract

Insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease whose onset is believed to be triggered by unknown environmental factors acting on a predisposing genetic background. Islet-infiltrating T(IIT) cells from two IDDM patients, who had died at the onset of the disease from brain swelling as a complication of ketoacidosis, were analysed. The results provided evidence for the involvement of a pancreatic islet cell membrane-bound superantigen as a diabetes aetiopathogenetic factor. There was a selective expansion of a T-cell receptor (TCR) variable segment of the β-chain (Vβ7) in these IIT cells in association with unselected Vα-chain segments; extensive junctional diversity of the TCR Vβ7 chains; and evidence of positive selection, after exposure to diabetic islet cell membrane preparations, of Vβ7+ T-cell clones among peripheral blood lymphocytes from non-diabetic individuals.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalNature
Volume371
Issue number6495
DOIs
StatePublished - Sep 22 1994
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Conrad, B., Weidmann, E., Trucco, G., Rudert, W. A., Behboo, R., Ricordi, C., Rodriquez-Rilo, H., Finegold, D., & Trucco, M. (1994). Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature, 371(6495), 351-355. https://doi.org/10.1038/371351a0