Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons

Ian D. Hentall; Timothy R. White

doi:10.1016/S0006-8993(96)01236-X

Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons

Ian D. Hentall, Timothy R. White

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Raphe magnus cells that are inhibited by skin pinching fire spontaneously with strongly preferred interspike intervals (mean cycle 85 ms, n = 33). In pentobarbital-anesthetized rats, mid-cycle cathodal activation (0.3 ms) or end-cycle anodal block (30-60 ms) at ~ 1 Hz through the extracellular recording microelectrode delayed expected spikes; respective post-stimulus latencies peaked on avarage at 1.17 (n = 14) and 0.40 (n = 6) cycles. Feedback inhibition following random excitation, but not free-running intrinsic or afferent oscillations, may therefore cause the rhythm.

Original language	English (US)
Pages (from-to)	348-351
Number of pages	4
Journal	Brain research
Volume	745
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)01236-X
State	Published - Jan 16 1997
Externally published	Yes

Keywords

Autocorrelogram
Medulla
Microstimulation
Oscillation
Pain
Spike train

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(96)01236-X

Cite this

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title = "Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons",

abstract = "Raphe magnus cells that are inhibited by skin pinching fire spontaneously with strongly preferred interspike intervals (mean cycle 85 ms, n = 33). In pentobarbital-anesthetized rats, mid-cycle cathodal activation (0.3 ms) or end-cycle anodal block (30-60 ms) at ~ 1 Hz through the extracellular recording microelectrode delayed expected spikes; respective post-stimulus latencies peaked on avarage at 1.17 (n = 14) and 0.40 (n = 6) cycles. Feedback inhibition following random excitation, but not free-running intrinsic or afferent oscillations, may therefore cause the rhythm.",

keywords = "Autocorrelogram, Medulla, Microstimulation, Oscillation, Pain, Spike train",

author = "Hentall, {Ian D.} and White, {Timothy R.}",

note = "Funding Information: Supported by Grant NS26116 from the National Institutes of Health, and the Campus Research Board of the University of Illinois at Chicago. ",

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doi = "10.1016/S0006-8993(96)01236-X",

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T1 - Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons

AU - Hentall, Ian D.

AU - White, Timothy R.

N1 - Funding Information: Supported by Grant NS26116 from the National Institutes of Health, and the Campus Research Board of the University of Illinois at Chicago.

PY - 1997/1/16

Y1 - 1997/1/16

N2 - Raphe magnus cells that are inhibited by skin pinching fire spontaneously with strongly preferred interspike intervals (mean cycle 85 ms, n = 33). In pentobarbital-anesthetized rats, mid-cycle cathodal activation (0.3 ms) or end-cycle anodal block (30-60 ms) at ~ 1 Hz through the extracellular recording microelectrode delayed expected spikes; respective post-stimulus latencies peaked on avarage at 1.17 (n = 14) and 0.40 (n = 6) cycles. Feedback inhibition following random excitation, but not free-running intrinsic or afferent oscillations, may therefore cause the rhythm.

AB - Raphe magnus cells that are inhibited by skin pinching fire spontaneously with strongly preferred interspike intervals (mean cycle 85 ms, n = 33). In pentobarbital-anesthetized rats, mid-cycle cathodal activation (0.3 ms) or end-cycle anodal block (30-60 ms) at ~ 1 Hz through the extracellular recording microelectrode delayed expected spikes; respective post-stimulus latencies peaked on avarage at 1.17 (n = 14) and 0.40 (n = 6) cycles. Feedback inhibition following random excitation, but not free-running intrinsic or afferent oscillations, may therefore cause the rhythm.

KW - Autocorrelogram

KW - Medulla

KW - Microstimulation

KW - Oscillation

KW - Pain

KW - Spike train

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Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons

Abstract

Keywords

ASJC Scopus subject areas

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