Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome

Andrew C. Warren, Aravinda Chakravarti, Corinne Wong, Susan A. Slaugenhaupt, Susan H Blanton, Paul C. Watkins, Caterina Metaxotou, Stylianos E. Antonarakis

Research output: Contribution to journalArticle

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Abstract

Trisomy 21 usually results from nondisjunction during meiosis I. In order to determine whether nondisjunction results from failure of normal chromosome pairing or premature impairing, recombination frequencies were estimated between DNA polymorphic markers on the long arm of chromosome 21 in families containing one individual with trisomy 21. The recombination frequencies on chromosomes 21 that had undergone nondisjunction were then compared to those on chromosomes 21 that had disjoined normally. The data indicate that recombination is reduced between DNA markers on nondisjoined chromosomes 21. These results are consistent with the hypothesis that reduced chiasma formation predisposes to nondisjunction, resulting in trisomy 21 in humans.

Original languageEnglish
Pages (from-to)652-654
Number of pages3
JournalScience
Volume237
Issue number4815
StatePublished - Dec 1 1987
Externally publishedYes

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Chromosomes, Human, Pair 21
Down Syndrome
Genetic Recombination
Genetic Markers
Chromosome Pairing
Meiosis

ASJC Scopus subject areas

  • General

Cite this

Warren, A. C., Chakravarti, A., Wong, C., Slaugenhaupt, S. A., Blanton, S. H., Watkins, P. C., ... Antonarakis, S. E. (1987). Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome. Science, 237(4815), 652-654.

Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome. / Warren, Andrew C.; Chakravarti, Aravinda; Wong, Corinne; Slaugenhaupt, Susan A.; Blanton, Susan H; Watkins, Paul C.; Metaxotou, Caterina; Antonarakis, Stylianos E.

In: Science, Vol. 237, No. 4815, 01.12.1987, p. 652-654.

Research output: Contribution to journalArticle

Warren, AC, Chakravarti, A, Wong, C, Slaugenhaupt, SA, Blanton, SH, Watkins, PC, Metaxotou, C & Antonarakis, SE 1987, 'Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome', Science, vol. 237, no. 4815, pp. 652-654.
Warren AC, Chakravarti A, Wong C, Slaugenhaupt SA, Blanton SH, Watkins PC et al. Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome. Science. 1987 Dec 1;237(4815):652-654.
Warren, Andrew C. ; Chakravarti, Aravinda ; Wong, Corinne ; Slaugenhaupt, Susan A. ; Blanton, Susan H ; Watkins, Paul C. ; Metaxotou, Caterina ; Antonarakis, Stylianos E. / Evidence for reduced recombination on the nondisjoined chromosomes 21 in down syndrome. In: Science. 1987 ; Vol. 237, No. 4815. pp. 652-654.
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