Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain

Beáta Búzás, Sari Izenwasser, Philip S. Portoghese, Brian M. Cox

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Opioid agonists selective for mu- or delta opioid receptors inhibit adenyl yl cyclase in membranes from rat caudate-putamen and nucleus accumbens. The presence of subtypes of delta opioid receptors has been suggested. In both brain regions we have found that the inhibition of adenylyl cyclase by DPDPE was more readily antagonized by 7-benzylidenenaltrexone (BNTX), than by naltriben. In contrast, the inhibitory effects of deltorphin-II and DSLET were more readily antagonized by naltriben, than by BNTX. neither naltriben nor BNTX significantly antagonized the effect of a mu selective agonist. These results suggest that inhibition of adenylyl cyclase in caudate-putamen and nucleus accumbens is regulated by two forms of delta-opioid receptor with ligand selectivities similar to those two forms proposed to mediate analgesic effect.

Original languageEnglish (US)
Pages (from-to)PL101-PL106
JournalLife Sciences
Volume54
Issue number7
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain'. Together they form a unique fingerprint.

  • Cite this