Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy.

J. R. Mendell, S. Kolkin, J. T. Kissel, K. L. Weiss, D. W. Chakeres, Kottil W Rammohan

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

It is unclear whether sporadic reports of concurrent multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) represent coincidence or whether these two demyelinating disorders are pathogenically related. We utilized the sensitivity of magnetic resonance imaging (MRI) in detecting central nervous system (CNS) lesions to investigate 16 patients with CIDP. Six of the 16 had periventricular, subcortical, and brainstem white matter lesions indistinguishable from those seen in MS. Three of these patients had definite clinical and laboratory evidence of MS; three others with abnormal MRIs had no findings indicative of CNS disease. Previous reports have indicated that a significant number of MS patients have peripheral nerve demyelination. Our study suggests that many CIDP patients have concurrent CNS demyelination. Taken together, these observations support the existence of a central-peripheral inflammatory demyelinating syndrome. Whether this combined demyelinating syndrome lies on a spectrum between MS and CIDP or is a separate pathogenic entity will require further investigation.

Original languageEnglish
Pages (from-to)1291-1294
Number of pages4
JournalNeurology
Volume37
Issue number8
StatePublished - Aug 1 1987
Externally publishedYes

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Demyelinating Diseases
Multiple Sclerosis
Central Nervous System
Central Nervous System Diseases
Peripheral Nerves
Brain Stem
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mendell, J. R., Kolkin, S., Kissel, J. T., Weiss, K. L., Chakeres, D. W., & Rammohan, K. W. (1987). Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy. Neurology, 37(8), 1291-1294.

Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy. / Mendell, J. R.; Kolkin, S.; Kissel, J. T.; Weiss, K. L.; Chakeres, D. W.; Rammohan, Kottil W.

In: Neurology, Vol. 37, No. 8, 01.08.1987, p. 1291-1294.

Research output: Contribution to journalArticle

Mendell, JR, Kolkin, S, Kissel, JT, Weiss, KL, Chakeres, DW & Rammohan, KW 1987, 'Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy.', Neurology, vol. 37, no. 8, pp. 1291-1294.
Mendell, J. R. ; Kolkin, S. ; Kissel, J. T. ; Weiss, K. L. ; Chakeres, D. W. ; Rammohan, Kottil W. / Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy. In: Neurology. 1987 ; Vol. 37, No. 8. pp. 1291-1294.
@article{7ced630f968f4536abf90c70ac91bec6,
title = "Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy.",
abstract = "It is unclear whether sporadic reports of concurrent multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) represent coincidence or whether these two demyelinating disorders are pathogenically related. We utilized the sensitivity of magnetic resonance imaging (MRI) in detecting central nervous system (CNS) lesions to investigate 16 patients with CIDP. Six of the 16 had periventricular, subcortical, and brainstem white matter lesions indistinguishable from those seen in MS. Three of these patients had definite clinical and laboratory evidence of MS; three others with abnormal MRIs had no findings indicative of CNS disease. Previous reports have indicated that a significant number of MS patients have peripheral nerve demyelination. Our study suggests that many CIDP patients have concurrent CNS demyelination. Taken together, these observations support the existence of a central-peripheral inflammatory demyelinating syndrome. Whether this combined demyelinating syndrome lies on a spectrum between MS and CIDP or is a separate pathogenic entity will require further investigation.",
author = "Mendell, {J. R.} and S. Kolkin and Kissel, {J. T.} and Weiss, {K. L.} and Chakeres, {D. W.} and Rammohan, {Kottil W}",
year = "1987",
month = "8",
day = "1",
language = "English",
volume = "37",
pages = "1291--1294",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy.

AU - Mendell, J. R.

AU - Kolkin, S.

AU - Kissel, J. T.

AU - Weiss, K. L.

AU - Chakeres, D. W.

AU - Rammohan, Kottil W

PY - 1987/8/1

Y1 - 1987/8/1

N2 - It is unclear whether sporadic reports of concurrent multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) represent coincidence or whether these two demyelinating disorders are pathogenically related. We utilized the sensitivity of magnetic resonance imaging (MRI) in detecting central nervous system (CNS) lesions to investigate 16 patients with CIDP. Six of the 16 had periventricular, subcortical, and brainstem white matter lesions indistinguishable from those seen in MS. Three of these patients had definite clinical and laboratory evidence of MS; three others with abnormal MRIs had no findings indicative of CNS disease. Previous reports have indicated that a significant number of MS patients have peripheral nerve demyelination. Our study suggests that many CIDP patients have concurrent CNS demyelination. Taken together, these observations support the existence of a central-peripheral inflammatory demyelinating syndrome. Whether this combined demyelinating syndrome lies on a spectrum between MS and CIDP or is a separate pathogenic entity will require further investigation.

AB - It is unclear whether sporadic reports of concurrent multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) represent coincidence or whether these two demyelinating disorders are pathogenically related. We utilized the sensitivity of magnetic resonance imaging (MRI) in detecting central nervous system (CNS) lesions to investigate 16 patients with CIDP. Six of the 16 had periventricular, subcortical, and brainstem white matter lesions indistinguishable from those seen in MS. Three of these patients had definite clinical and laboratory evidence of MS; three others with abnormal MRIs had no findings indicative of CNS disease. Previous reports have indicated that a significant number of MS patients have peripheral nerve demyelination. Our study suggests that many CIDP patients have concurrent CNS demyelination. Taken together, these observations support the existence of a central-peripheral inflammatory demyelinating syndrome. Whether this combined demyelinating syndrome lies on a spectrum between MS and CIDP or is a separate pathogenic entity will require further investigation.

UR - http://www.scopus.com/inward/record.url?scp=0023388347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023388347&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 1291

EP - 1294

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -