Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension

Noam Alperin, Byron L Lam, Rong Wen Tain, Sudarshan Ranganathan, Michael Letzing, Maria Bloom, Benny Alexander, Potyra R. Aroucha, Evelyn Sklar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, is a debilitating neurological disorder characterized by elevated CSF pressure of unknown cause. IIH manifests as severe headaches, and visual impairments. Most typically, IIH prevails in overweight females of childbearing age and its incidence is rising in parallel with the obesity epidemic. The most accepted theory for the cause of IIH is reduced absorption of CSF due to elevated intracranial venous pressure. A comprehensive MRI study, which includes structural and physiological imaging, was applied to characterize morphological and physiological differences between a homogeneous cohort of female IIH patients and an age-and BMI-similar control group to further elucidate the underlying pathophysiology. A novel analysis of MRI measurements of blood and CSF flow to and from the cranial and spinal canal compartments employing lumped parameters modeling of the cranio-spinal biomechanics provided, for the first time, evidence for the involvement of the spinal canal compartment. The CSF space in the spinal canal is less confined by bony structures compared with the cranial CSF, thereby providing most of the craniospinal compliance. This study demonstrates that the contribution of spinal canal compliance in IIH is significantly reduced.

Original languageEnglish (US)
Title of host publicationIntracranial Pressure and Brain Monitoring XIV
PublisherSpringer-Verlag Wien
Pages201-205
Number of pages5
Edition114
ISBN (Print)9783709109557
DOIs
StatePublished - Jan 1 2012

Publication series

NameActa Neurochirurgica, Supplementum
Number114
ISSN (Print)0065-1419
ISSN (Electronic)0001-6268

Fingerprint

Pseudotumor Cerebri
Spinal Canal
Compliance
Drainage
Venous Pressure
Intracranial Hypertension
Vision Disorders
Nervous System Diseases
Biomechanical Phenomena
Headache
Obesity
Pressure
Control Groups
Incidence

Keywords

  • Cerebral venous drainage
  • Cranio-spinal biomechanical properties
  • Intracranial hypertension
  • MRI CSF and blood flow studies
  • Underlying pathophysiology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Alperin, N., Lam, B. L., Tain, R. W., Ranganathan, S., Letzing, M., Bloom, M., ... Sklar, E. (2012). Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension. In Intracranial Pressure and Brain Monitoring XIV (114 ed., pp. 201-205). (Acta Neurochirurgica, Supplementum; No. 114). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0956-4_39

Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension. / Alperin, Noam; Lam, Byron L; Tain, Rong Wen; Ranganathan, Sudarshan; Letzing, Michael; Bloom, Maria; Alexander, Benny; Aroucha, Potyra R.; Sklar, Evelyn.

Intracranial Pressure and Brain Monitoring XIV. 114. ed. Springer-Verlag Wien, 2012. p. 201-205 (Acta Neurochirurgica, Supplementum; No. 114).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Alperin, N, Lam, BL, Tain, RW, Ranganathan, S, Letzing, M, Bloom, M, Alexander, B, Aroucha, PR & Sklar, E 2012, Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension. in Intracranial Pressure and Brain Monitoring XIV. 114 edn, Acta Neurochirurgica, Supplementum, no. 114, Springer-Verlag Wien, pp. 201-205. https://doi.org/10.1007/978-3-7091-0956-4_39
Alperin N, Lam BL, Tain RW, Ranganathan S, Letzing M, Bloom M et al. Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension. In Intracranial Pressure and Brain Monitoring XIV. 114 ed. Springer-Verlag Wien. 2012. p. 201-205. (Acta Neurochirurgica, Supplementum; 114). https://doi.org/10.1007/978-3-7091-0956-4_39
Alperin, Noam ; Lam, Byron L ; Tain, Rong Wen ; Ranganathan, Sudarshan ; Letzing, Michael ; Bloom, Maria ; Alexander, Benny ; Aroucha, Potyra R. ; Sklar, Evelyn. / Evidence for altered spinal canal compliance and cerebral venous drainage in untreated idiopathic intracranial hypertension. Intracranial Pressure and Brain Monitoring XIV. 114. ed. Springer-Verlag Wien, 2012. pp. 201-205 (Acta Neurochirurgica, Supplementum; 114).
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