Abstract
Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 379-382 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 385 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 22 1986 |
| Externally published | Yes |
Keywords
- Amphetamine
- Dihydroxyphenylacetic acid
- Dopamine
- Dopamine release
- Immunoneutralization
- Locomotor activity
- Nucleus accumbens
- Subtance P
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Elliott, P. J., Nemeroff, C. B., & Kilts, C. D. (1986). Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens. Brain Research, 385(2), 379-382. https://doi.org/10.1016/0006-8993(86)91087-5