Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Peter J. Elliott; Charles B. Nemeroff; Clinton D. Kilts

doi:10.1016/0006-8993(86)91087-5

Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Peter J. Elliott, Charles B. Nemeroff, Clinton D. Kilts

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.

Original language	English (US)
Pages (from-to)	379-382
Number of pages	4
Journal	Brain research
Volume	385
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)91087-5
State	Published - Oct 22 1986
Externally published	Yes

Keywords

Amphetamine
Dihydroxyphenylacetic acid
Dopamine
Dopamine release
Immunoneutralization
Locomotor activity
Nucleus accumbens
Subtance P

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(86)91087-5

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@article{fae637fcbbcc4eddbe31a7a7cf78254b,

title = "Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens",

abstract = "Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.",

keywords = "Amphetamine, Dihydroxyphenylacetic acid, Dopamine, Dopamine release, Immunoneutralization, Locomotor activity, Nucleus accumbens, Subtance P",

author = "Elliott, {Peter J.} and Nemeroff, {Charles B.} and Kilts, {Clinton D.}",

note = "Funding Information: We are grateful to Gail Atwater and Mrs. Angelika Mayes for typing this manuscript and to Laura E1-liott for drawing the figures. P.J.E. was the recipient of the Gorrell Family Psychiatric Research Fellowship from Duke University Medical Center. This work was supported by NIMH MH-39967 and NIMH MH-39415.",

year = "1986",

month = oct,

day = "22",

doi = "10.1016/0006-8993(86)91087-5",

language = "English (US)",

volume = "385",

pages = "379--382",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

AU - Elliott, Peter J.

AU - Nemeroff, Charles B.

AU - Kilts, Clinton D.

N1 - Funding Information: We are grateful to Gail Atwater and Mrs. Angelika Mayes for typing this manuscript and to Laura E1-liott for drawing the figures. P.J.E. was the recipient of the Gorrell Family Psychiatric Research Fellowship from Duke University Medical Center. This work was supported by NIMH MH-39967 and NIMH MH-39415.

PY - 1986/10/22

Y1 - 1986/10/22

N2 - Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.

AB - Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.

KW - Amphetamine

KW - Dihydroxyphenylacetic acid

KW - Dopamine

KW - Dopamine release

KW - Immunoneutralization

KW - Locomotor activity

KW - Nucleus accumbens

KW - Subtance P

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U2 - 10.1016/0006-8993(86)91087-5

DO - 10.1016/0006-8993(86)91087-5

M3 - Article

C2 - 2430671

AN - SCOPUS:0022454692

VL - 385

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EP - 382

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Abstract

Keywords

ASJC Scopus subject areas

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