Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Peter J. Elliott; Charles B. Nemeroff; Clinton D. Kilts

doi:10.1016/0006-8993(86)91087-5

Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Peter J. Elliott, Charles B. Nemeroff, Clinton D. Kilts

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.

Original language	English (US)
Pages (from-to)	379-382
Number of pages	4
Journal	Brain Research
Volume	385
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)91087-5
State	Published - Oct 22 1986
Externally published	Yes

Keywords

Amphetamine
Dihydroxyphenylacetic acid
Dopamine
Dopamine release
Immunoneutralization
Locomotor activity
Nucleus accumbens
Subtance P

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(86)91087-5

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title = "Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens",

abstract = "Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.",

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AU - Nemeroff, Charles B.

AU - Kilts, Clinton D.

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