Abstract
Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.
Original language | English (US) |
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Pages (from-to) | 379-382 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 385 |
Issue number | 2 |
DOIs | |
State | Published - Oct 22 1986 |
Externally published | Yes |
Keywords
- Amphetamine
- Dihydroxyphenylacetic acid
- Dopamine
- Dopamine release
- Immunoneutralization
- Locomotor activity
- Nucleus accumbens
- Subtance P
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)