Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens

Peter J. Elliott, Charles B. Nemeroff, Clinton D. Kilts

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Microinjections of a monoclonal antibody substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenyllacetic acid (DOPAC) in the NAS but not neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered d-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or d-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalBrain Research
Volume385
Issue number2
DOIs
StatePublished - Oct 22 1986
Externally publishedYes

Keywords

  • Amphetamine
  • Dihydroxyphenylacetic acid
  • Dopamine
  • Dopamine release
  • Immunoneutralization
  • Locomotor activity
  • Nucleus accumbens
  • Subtance P

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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