Evidence for a locus regulating total serum ige levels mapping to chromosome 5

D. A. Meyers, D. S. Postma, C. I.M. Panhuysen, J. Xu, P. J. Amelung, R. C. Levitt, E. R. Bleecker

Research output: Contribution to journalArticle

345 Scopus citations

Abstract

Genetics studies of total serum IgE levels were performed since high IgE levels correlate with clinical expression of allergy and asthma. Families ascertained through a parent with asthma were genotyped for markers on 5q where there are multiple candidate genes that may influence the control of IgE and inflammation. Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score analysis with evidence for recessive inheritance of high IgE levels from segregation analysis. These findings represent a major step in mapping genes important in the regulation of allergic responses and the pathogenesis of asthma.

Original languageEnglish (US)
Pages (from-to)464-470
Number of pages7
JournalGenomics
Volume23
Issue number2
DOIs
StatePublished - Sep 15 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Meyers, D. A., Postma, D. S., Panhuysen, C. I. M., Xu, J., Amelung, P. J., Levitt, R. C., & Bleecker, E. R. (1994). Evidence for a locus regulating total serum ige levels mapping to chromosome 5. Genomics, 23(2), 464-470. https://doi.org/10.1006/geno.1994.1524