Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood

Nathan A. Fox, Kate E. Nichols, Heather A. Henderson, Kenneth Rubin, Louis Schmidt, Dean Hamer, Monique Ernst, Daniel S. Pine

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalPsychological Science
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2005

Fingerprint

Gene-Environment Interaction
Social Support
Serotonin Plasma Membrane Transport Proteins
Genetic Promoter Regions
Individuality
Fear
Serotonin
Alleles
Mothers
Research
Genes
Inhibition (Psychology)

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K., Schmidt, L., Hamer, D., ... Pine, D. S. (2005). Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science, 16(12), 921-926. https://doi.org/10.1111/j.1467-9280.2005.01637.x

Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. / Fox, Nathan A.; Nichols, Kate E.; Henderson, Heather A.; Rubin, Kenneth; Schmidt, Louis; Hamer, Dean; Ernst, Monique; Pine, Daniel S.

In: Psychological Science, Vol. 16, No. 12, 01.12.2005, p. 921-926.

Research output: Contribution to journalArticle

Fox, NA, Nichols, KE, Henderson, HA, Rubin, K, Schmidt, L, Hamer, D, Ernst, M & Pine, DS 2005, 'Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood', Psychological Science, vol. 16, no. 12, pp. 921-926. https://doi.org/10.1111/j.1467-9280.2005.01637.x
Fox, Nathan A. ; Nichols, Kate E. ; Henderson, Heather A. ; Rubin, Kenneth ; Schmidt, Louis ; Hamer, Dean ; Ernst, Monique ; Pine, Daniel S. / Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. In: Psychological Science. 2005 ; Vol. 16, No. 12. pp. 921-926.
@article{7d00c28234b2465eb156d1674a62efe8,
title = "Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood",
abstract = "Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood.",
author = "Fox, {Nathan A.} and Nichols, {Kate E.} and Henderson, {Heather A.} and Kenneth Rubin and Louis Schmidt and Dean Hamer and Monique Ernst and Pine, {Daniel S.}",
year = "2005",
month = "12",
day = "1",
doi = "10.1111/j.1467-9280.2005.01637.x",
language = "English",
volume = "16",
pages = "921--926",
journal = "Psychological Science",
issn = "0956-7976",
publisher = "SAGE Publications Inc.",
number = "12",

}

TY - JOUR

T1 - Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood

AU - Fox, Nathan A.

AU - Nichols, Kate E.

AU - Henderson, Heather A.

AU - Rubin, Kenneth

AU - Schmidt, Louis

AU - Hamer, Dean

AU - Ernst, Monique

AU - Pine, Daniel S.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood.

AB - Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood.

UR - http://www.scopus.com/inward/record.url?scp=30344484828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30344484828&partnerID=8YFLogxK

U2 - 10.1111/j.1467-9280.2005.01637.x

DO - 10.1111/j.1467-9280.2005.01637.x

M3 - Article

C2 - 16313653

AN - SCOPUS:30344484828

VL - 16

SP - 921

EP - 926

JO - Psychological Science

JF - Psychological Science

SN - 0956-7976

IS - 12

ER -