Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues

T. Kayano, H. Fukumoto, R. L. Eddy, Y. S. Fan, M. G. Byers, T. B. Shows, G. I. Bell

Research output: Contribution to journalArticle

337 Scopus citations

Abstract

Complementary DNA clones encoding a glucose transporter-like protein have been isolated from a human fetal skeletal muscle cDNA library. The 496-amino acid fetal muscle glucose transporter-like protein has 64.4 and 51.6% identity with the previously described human erythrocyte/HepG2 and liver glucose transporter sequences, respectively. RNA blotting studies indicate that transcripts encoding this glucose transporter-like protein are present in most tissues, although their relative abundance varies. The gene encoding this protein has been localized to human chromosome 12p13.3. the identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells.

Original languageEnglish (US)
Pages (from-to)15245-15248
Number of pages4
JournalJournal of Biological Chemistry
Volume263
Issue number30
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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