Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors

Alice Zelmanowicz, Allan Hildesheim, Mark E. Sherman, Susan R. Sturgeon, Robert J. Kurman, Rolland J. Barrett, Michael L. Berman, Rodrigue Mortel, Leo B. Twiggs, George D. Wilbanks, Louise A. Brinton

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Objective. To elucidate factors linked to the development of malignant mixed mullerian tumors (MMMT) and determine whether the risk factor profile for these tumors corresponds with that for the more common endometrial carcinomas. Methods. A multicenter ease-control study of 424 women diagnosed with endometrial carcinoma, 29 women diagnosed with MMMT, and 320 community controls was conducted. Review of pathological reports and slides was performed to classify eases by histological type. All participants were asked to respond to a questionnaire which ascertained information on exposure to factors postulated to be linked to the development of uterine tumors. Results. Women with endometrial carcinomas and MMMTs were similar with respect to age and educational attainment. Women diagnosed with MMMTs were more likely than those diagnosed with carcinomas to be of African-American descent (28% vs 4%; P = 0.001). Weight, exogenous estrogen use, and nulliparity were related to risk of both tumor types. Marked obesity was associated with a 4.8-fold (95% CI = 3.0,7.6) increase in risk of carcinoma and a 3.2-fold (95% CI = 1.1,9.1) increase in risk of MMMT development. Use of exogenous estrogens increased the odds of developing carcinomas by 2-fold (95% CI = 1.3,3.2) and that of developing MMMTs by 1.8-fold (95% CI = 0.57,5.5). Nulliparity was associated with a 2.9-fold (95% CI = 1.9,4.8) increase in risk of carcinomas and a 1.7-fold (95% CI = 0.53,5.6) increase in risk of MMMTs. Oral contraceptive use protected against the development of both carcinomas (OR = 0.39; 95% CI = 0.26,0.58) and MMMTs (OR = 0.76; 95% CI = 0.25,2.3). Current smokers were at a reduced risk of developing endometrial carcinomas (OR = 0.34; 95% CI = 0.21,0.55) and MMMTs (OR = 0.57; 95% CI = 0.15,2.3), while former smokers were at an in- creased risk of MMMT (OR = 2.7; 95% CI = 1.1,6.8) but not carcinoma development (OR = 0.81; 95% CI = 0.56,1.2). Conclusion. Results from this study suggest that MMMTs and carcinomas have a similar risk factor profile. This observation is compatible with the hypothesis that the pathogenesis of these two histological types of uterine tumors is similar.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalGynecologic Oncology
Volume69
Issue number3
DOIs
StatePublished - Jun 1 1998
Externally publishedYes

Fingerprint

Malignant Mixed Tumor
Endometrial Neoplasms
Carcinoma
Parity
Neoplasms
Estrogens
Oral Contraceptives
African Americans
Obesity
Weights and Measures

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Zelmanowicz, A., Hildesheim, A., Sherman, M. E., Sturgeon, S. R., Kurman, R. J., Barrett, R. J., ... Brinton, L. A. (1998). Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors. Gynecologic Oncology, 69(3), 253-257. https://doi.org/10.1006/gyno.1998.4941

Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors. / Zelmanowicz, Alice; Hildesheim, Allan; Sherman, Mark E.; Sturgeon, Susan R.; Kurman, Robert J.; Barrett, Rolland J.; Berman, Michael L.; Mortel, Rodrigue; Twiggs, Leo B.; Wilbanks, George D.; Brinton, Louise A.

In: Gynecologic Oncology, Vol. 69, No. 3, 01.06.1998, p. 253-257.

Research output: Contribution to journalArticle

Zelmanowicz, A, Hildesheim, A, Sherman, ME, Sturgeon, SR, Kurman, RJ, Barrett, RJ, Berman, ML, Mortel, R, Twiggs, LB, Wilbanks, GD & Brinton, LA 1998, 'Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors', Gynecologic Oncology, vol. 69, no. 3, pp. 253-257. https://doi.org/10.1006/gyno.1998.4941
Zelmanowicz A, Hildesheim A, Sherman ME, Sturgeon SR, Kurman RJ, Barrett RJ et al. Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors. Gynecologic Oncology. 1998 Jun 1;69(3):253-257. https://doi.org/10.1006/gyno.1998.4941
Zelmanowicz, Alice ; Hildesheim, Allan ; Sherman, Mark E. ; Sturgeon, Susan R. ; Kurman, Robert J. ; Barrett, Rolland J. ; Berman, Michael L. ; Mortel, Rodrigue ; Twiggs, Leo B. ; Wilbanks, George D. ; Brinton, Louise A. / Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors. In: Gynecologic Oncology. 1998 ; Vol. 69, No. 3. pp. 253-257.
@article{7c04eec805b645d183c061544789b5c2,
title = "Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors",
abstract = "Objective. To elucidate factors linked to the development of malignant mixed mullerian tumors (MMMT) and determine whether the risk factor profile for these tumors corresponds with that for the more common endometrial carcinomas. Methods. A multicenter ease-control study of 424 women diagnosed with endometrial carcinoma, 29 women diagnosed with MMMT, and 320 community controls was conducted. Review of pathological reports and slides was performed to classify eases by histological type. All participants were asked to respond to a questionnaire which ascertained information on exposure to factors postulated to be linked to the development of uterine tumors. Results. Women with endometrial carcinomas and MMMTs were similar with respect to age and educational attainment. Women diagnosed with MMMTs were more likely than those diagnosed with carcinomas to be of African-American descent (28{\%} vs 4{\%}; P = 0.001). Weight, exogenous estrogen use, and nulliparity were related to risk of both tumor types. Marked obesity was associated with a 4.8-fold (95{\%} CI = 3.0,7.6) increase in risk of carcinoma and a 3.2-fold (95{\%} CI = 1.1,9.1) increase in risk of MMMT development. Use of exogenous estrogens increased the odds of developing carcinomas by 2-fold (95{\%} CI = 1.3,3.2) and that of developing MMMTs by 1.8-fold (95{\%} CI = 0.57,5.5). Nulliparity was associated with a 2.9-fold (95{\%} CI = 1.9,4.8) increase in risk of carcinomas and a 1.7-fold (95{\%} CI = 0.53,5.6) increase in risk of MMMTs. Oral contraceptive use protected against the development of both carcinomas (OR = 0.39; 95{\%} CI = 0.26,0.58) and MMMTs (OR = 0.76; 95{\%} CI = 0.25,2.3). Current smokers were at a reduced risk of developing endometrial carcinomas (OR = 0.34; 95{\%} CI = 0.21,0.55) and MMMTs (OR = 0.57; 95{\%} CI = 0.15,2.3), while former smokers were at an in- creased risk of MMMT (OR = 2.7; 95{\%} CI = 1.1,6.8) but not carcinoma development (OR = 0.81; 95{\%} CI = 0.56,1.2). Conclusion. Results from this study suggest that MMMTs and carcinomas have a similar risk factor profile. This observation is compatible with the hypothesis that the pathogenesis of these two histological types of uterine tumors is similar.",
author = "Alice Zelmanowicz and Allan Hildesheim and Sherman, {Mark E.} and Sturgeon, {Susan R.} and Kurman, {Robert J.} and Barrett, {Rolland J.} and Berman, {Michael L.} and Rodrigue Mortel and Twiggs, {Leo B.} and Wilbanks, {George D.} and Brinton, {Louise A.}",
year = "1998",
month = "6",
day = "1",
doi = "10.1006/gyno.1998.4941",
language = "English",
volume = "69",
pages = "253--257",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors

AU - Zelmanowicz, Alice

AU - Hildesheim, Allan

AU - Sherman, Mark E.

AU - Sturgeon, Susan R.

AU - Kurman, Robert J.

AU - Barrett, Rolland J.

AU - Berman, Michael L.

AU - Mortel, Rodrigue

AU - Twiggs, Leo B.

AU - Wilbanks, George D.

AU - Brinton, Louise A.

PY - 1998/6/1

Y1 - 1998/6/1

N2 - Objective. To elucidate factors linked to the development of malignant mixed mullerian tumors (MMMT) and determine whether the risk factor profile for these tumors corresponds with that for the more common endometrial carcinomas. Methods. A multicenter ease-control study of 424 women diagnosed with endometrial carcinoma, 29 women diagnosed with MMMT, and 320 community controls was conducted. Review of pathological reports and slides was performed to classify eases by histological type. All participants were asked to respond to a questionnaire which ascertained information on exposure to factors postulated to be linked to the development of uterine tumors. Results. Women with endometrial carcinomas and MMMTs were similar with respect to age and educational attainment. Women diagnosed with MMMTs were more likely than those diagnosed with carcinomas to be of African-American descent (28% vs 4%; P = 0.001). Weight, exogenous estrogen use, and nulliparity were related to risk of both tumor types. Marked obesity was associated with a 4.8-fold (95% CI = 3.0,7.6) increase in risk of carcinoma and a 3.2-fold (95% CI = 1.1,9.1) increase in risk of MMMT development. Use of exogenous estrogens increased the odds of developing carcinomas by 2-fold (95% CI = 1.3,3.2) and that of developing MMMTs by 1.8-fold (95% CI = 0.57,5.5). Nulliparity was associated with a 2.9-fold (95% CI = 1.9,4.8) increase in risk of carcinomas and a 1.7-fold (95% CI = 0.53,5.6) increase in risk of MMMTs. Oral contraceptive use protected against the development of both carcinomas (OR = 0.39; 95% CI = 0.26,0.58) and MMMTs (OR = 0.76; 95% CI = 0.25,2.3). Current smokers were at a reduced risk of developing endometrial carcinomas (OR = 0.34; 95% CI = 0.21,0.55) and MMMTs (OR = 0.57; 95% CI = 0.15,2.3), while former smokers were at an in- creased risk of MMMT (OR = 2.7; 95% CI = 1.1,6.8) but not carcinoma development (OR = 0.81; 95% CI = 0.56,1.2). Conclusion. Results from this study suggest that MMMTs and carcinomas have a similar risk factor profile. This observation is compatible with the hypothesis that the pathogenesis of these two histological types of uterine tumors is similar.

AB - Objective. To elucidate factors linked to the development of malignant mixed mullerian tumors (MMMT) and determine whether the risk factor profile for these tumors corresponds with that for the more common endometrial carcinomas. Methods. A multicenter ease-control study of 424 women diagnosed with endometrial carcinoma, 29 women diagnosed with MMMT, and 320 community controls was conducted. Review of pathological reports and slides was performed to classify eases by histological type. All participants were asked to respond to a questionnaire which ascertained information on exposure to factors postulated to be linked to the development of uterine tumors. Results. Women with endometrial carcinomas and MMMTs were similar with respect to age and educational attainment. Women diagnosed with MMMTs were more likely than those diagnosed with carcinomas to be of African-American descent (28% vs 4%; P = 0.001). Weight, exogenous estrogen use, and nulliparity were related to risk of both tumor types. Marked obesity was associated with a 4.8-fold (95% CI = 3.0,7.6) increase in risk of carcinoma and a 3.2-fold (95% CI = 1.1,9.1) increase in risk of MMMT development. Use of exogenous estrogens increased the odds of developing carcinomas by 2-fold (95% CI = 1.3,3.2) and that of developing MMMTs by 1.8-fold (95% CI = 0.57,5.5). Nulliparity was associated with a 2.9-fold (95% CI = 1.9,4.8) increase in risk of carcinomas and a 1.7-fold (95% CI = 0.53,5.6) increase in risk of MMMTs. Oral contraceptive use protected against the development of both carcinomas (OR = 0.39; 95% CI = 0.26,0.58) and MMMTs (OR = 0.76; 95% CI = 0.25,2.3). Current smokers were at a reduced risk of developing endometrial carcinomas (OR = 0.34; 95% CI = 0.21,0.55) and MMMTs (OR = 0.57; 95% CI = 0.15,2.3), while former smokers were at an in- creased risk of MMMT (OR = 2.7; 95% CI = 1.1,6.8) but not carcinoma development (OR = 0.81; 95% CI = 0.56,1.2). Conclusion. Results from this study suggest that MMMTs and carcinomas have a similar risk factor profile. This observation is compatible with the hypothesis that the pathogenesis of these two histological types of uterine tumors is similar.

UR - http://www.scopus.com/inward/record.url?scp=0032103255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032103255&partnerID=8YFLogxK

U2 - 10.1006/gyno.1998.4941

DO - 10.1006/gyno.1998.4941

M3 - Article

VL - 69

SP - 253

EP - 257

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -