Some antidepressants may be efficacious in alleviating pain. While few studies have directly compared antidepressants for the treatment of painful physical symptoms, meta-analyses of efficacy studies have found that antidepressants that act at serotonergic and noradrenergic neurotransmitters, such as some tricyclics and serotonin- norepinephrine reuptake inhibitors (SNRIs), may alleviate pain independently of their effects on mood. These dual-action agents have more consistently shown efficacy for pain than single-action agents.
ASJC Scopus subject areas
- Psychiatry and Mental health