Evidence-Based Review of Clinical Applications and Outcomes of Automated Epidermal Grafting

Azam A. Qureshi, Robert S. Kirsner

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Commercialization of an automated epidermal harvesting device (CelluTome™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes. Recent Findings: A total of 20 published reports including 284 automated graft recipients have been published. Complete reepithelialization occurs in 50–92% of recipient sites, often within 4–18 weeks of graft placement. Donor sites heal without scarring within 1–2 weeks. Summary: Current evidence suggests efficacy in using an automated epidermal harvesting device for the wounds of patients with multiple comorbidities and failing previous treatments for their wounds, including vascular ulcers, diabetic ulcers, surgical wounds, complex wounds, acute traumatic wounds, pyoderma gangrenosum, and burns. Limited evidence also suggests efficacy of automated epidermal grafting for disorders of pigmentation. Better trials studying individual clinical applications of epidermal grafting are needed.

Original languageEnglish (US)
Pages (from-to)182-189
Number of pages8
JournalCurrent Dermatology Reports
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2019

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Wounds and Injuries
Ulcer
Pigmentation Disorders
Pyoderma Gangrenosum
Transplants
Equipment and Supplies
Burns
Cicatrix
Blood Vessels
Publications
Comorbidity
Tissue Donors
Therapeutics
Surgical Wound

Keywords

  • Epidermal skin graft
  • Pigmentation disorders
  • Vitiligo
  • Wound healing

ASJC Scopus subject areas

  • Dermatology

Cite this

Evidence-Based Review of Clinical Applications and Outcomes of Automated Epidermal Grafting. / Qureshi, Azam A.; Kirsner, Robert S.

In: Current Dermatology Reports, Vol. 8, No. 4, 01.12.2019, p. 182-189.

Research output: Contribution to journalReview article

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abstract = "Purpose of Review: Commercialization of an automated epidermal harvesting device (CelluTome™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes. Recent Findings: A total of 20 published reports including 284 automated graft recipients have been published. Complete reepithelialization occurs in 50–92{\%} of recipient sites, often within 4–18 weeks of graft placement. Donor sites heal without scarring within 1–2 weeks. Summary: Current evidence suggests efficacy in using an automated epidermal harvesting device for the wounds of patients with multiple comorbidities and failing previous treatments for their wounds, including vascular ulcers, diabetic ulcers, surgical wounds, complex wounds, acute traumatic wounds, pyoderma gangrenosum, and burns. Limited evidence also suggests efficacy of automated epidermal grafting for disorders of pigmentation. Better trials studying individual clinical applications of epidermal grafting are needed.",
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