Evidence-based data on pain relief with antidepressants

David A Fishbain

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

This structured review addresses the issue of whether antidepressants have an antinociceptive (analgesic) effect for chronic pain independent of their antidepressant effect. In order to answer this question, human acute pain studies, individual placebo-controlled studies for the treatment of specific chronic pain syndromes, and metaanalytic studies were reviewed and placed into table format. Analysis of this evidence led to the following conclusions: The evidence was consistent in indicating that overall antidepressants may have an antinociceptive effect in chronic pain, and that these drugs were effective for neuropathic pain. There was also some evidence that these drugs could be effective for psychogenic or somatoform disorder-associated pain. This evidence also strongly suggested that serotonergic-noradrenergic antidepressants may have a more consistent antinociceptive effect than the serotonergic antidepressants. Finally, this evidence indicated that antidepressants could be effective for pain associated with some specific pain syndromes, such as chronic low back pain, osteoarthritis or rheumatoid arthritis, fibrositis or fibromyalgia, and ulcer healing. Possible reasons for the conflicting results of studies in this area are presented, and problems that could limit the validity of the conclusions of this review are discussed.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalAnnals of Medicine
Volume32
Issue number5
StatePublished - Aug 12 2000

Fingerprint

Antidepressive Agents
Pain
Chronic Pain
Fibromyalgia
Somatoform Disorders
Acute Pain
Neuralgia
Low Back Pain
Osteoarthritis
Pharmaceutical Preparations
Ulcer
Analgesics
Rheumatoid Arthritis
Placebos

Keywords

  • Antidepressants
  • Antinociceptive effect
  • Chronic pain
  • Fibromyalgia
  • Headache
  • Serotonergic antidepressants
  • Serotonergic- noradrenergic antidepressants
  • Structured review

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evidence-based data on pain relief with antidepressants. / Fishbain, David A.

In: Annals of Medicine, Vol. 32, No. 5, 12.08.2000, p. 305-316.

Research output: Contribution to journalArticle

Fishbain, DA 2000, 'Evidence-based data on pain relief with antidepressants', Annals of Medicine, vol. 32, no. 5, pp. 305-316.
Fishbain, David A. / Evidence-based data on pain relief with antidepressants. In: Annals of Medicine. 2000 ; Vol. 32, No. 5. pp. 305-316.
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