Evidence-based best practice advice for patients treated with systemic immunosuppressants in relation to COVID-19

Fabrizio Galimberti, Jeffrey McBride, Megan Cronin, Yumeng Li, Joshua Fox, Michael Abrouk, Alexander Herbst, Robert S. Kirsner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The emergence of the COVID-19 pandemic has led to significant uncertainty among physicians and patients about the safety of immunosuppressive medications used for the management of dermatologic conditions. We review available data on commonly used immunosuppressants and their effect on viral infections beyond COVID-19. Notably, the effect of some immunosuppressants on viruses related to SARS-CoV2, including SARS and MERS, has been previously investigated. In the absence of data on the effect of immunosuppressants on COVID-19, these data could be used to make clinical decisions on initiation and continuation of immunosuppressive medications during this pandemic. In summary, we recommend considering the discontinuation of oral Janus kinase (JAK) inhibitors and prednisone; considering the delay of rituximab infusion; and suggesting the careful continuation of cyclosporine, mycophenolate, azathioprine, methotrexate, and biologics in patients currently benefitting from such treatments.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalClinics in Dermatology
Volume38
Issue number6
DOIs
StatePublished - Nov 1 2020

ASJC Scopus subject areas

  • Dermatology

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