Abstract
Purpose: To evaluate the surgical learning curve in episceral plaque brachytherapy placement in the management of posterior uveal melanoma. Methods: A retrospective chart review of two cohorts of 250 consecutive patients undergoing plaque placement for posterior uveal melanoma from 2002 to 2004 and from 2008 to 2009 was conducted. The plaque-tumor apposition rates verified by intraoperative echography were evaluated and correlated with surgical volume over a 19-year period. Results: In an initial study of 29 consecutive patients undergoing plaque placement from January 1992 to January 1995, a suboptimal plaque placement rate of 21% (n = 29) was identified. This percentage declined to 12% (n = 100) from January 2002 to January 2004, and further declined to 4% (n = 150) from June 2008 to August 2009. The tumor-plaque apposition rates for these three groups were 79% (1992-1995), 88% (2002-2004), and 96% (2008-2009). An estimated surgical volume of 1275 cases was performed to achieve a > 90% precision rate for first application of primary plaque centration. Conclusion: There are challenges to mastering the precise placement of radioactive plaques for posterior uveal melanoma. We have demonstrated a significant learning curve for plaque placement techniques, and have emphasized the importance of intraoperative ultrasound in the verification of plaque placement, thus allowing for intraoperative repositioning.
Original language | English (US) |
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Pages (from-to) | 447-452 |
Number of pages | 6 |
Journal | Clinical Ophthalmology |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - 2012 |
Keywords
- Brachytherapy
- Intraoperative ultrasound
- Ocular oncology
ASJC Scopus subject areas
- Ophthalmology