TY - JOUR
T1 - Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy
AU - Takacs, Peter
AU - Chakhtoura, Nahida
AU - De Santis, Timothy
AU - Verma, Usha
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Objective: To test the hypothesis that endometrial stripe thicker than 12 mm increases treatment failure of single-dose methotrexate for the management of ectopic pregnancy. Study design: Seventy-three patients with ectopic pregnancy and measured pretreatment endometrial stripe were divided into two groups based on the endometrial stripe thickness (>12 mm or ≤ 12 mm). All patients were candidates for single-dose methotrexate treatment. Variables analyzed between the two groups were endometrial stripe thickness, initial beta human chorionic gonadotropin level (hCG), size of the ectopic mass, presence of fetal heart tones, previous ectopic pregnancy, and clinical outcomes. Results: Sixty patients had endometrial stripe thickness ≤ 12 mm and 13 patients >12 mm. The two groups were similar in initial hCG, size of ectopic mass, presence of fetal heart tones and rate of previous ectopic pregnancy. The failure rate was significantly higher in the group with endometrial stripe >12 mm compared to the group ≤ 12 mm (n=7, 53% vs. n=3, 5%, P<0.01). The endometrial stripe was significantly thicker in the group with endometrial stripe thickness >12 mm compared to the group ≤ 12 mm (mean ± SD, 17.64±5.82 mm vs. 7.69±2.82 mm, P<0.01). Conclusion: Endometrial stripe thicker than 12 mm increases the risk for treatment failure with single-dose methotrexate.
AB - Objective: To test the hypothesis that endometrial stripe thicker than 12 mm increases treatment failure of single-dose methotrexate for the management of ectopic pregnancy. Study design: Seventy-three patients with ectopic pregnancy and measured pretreatment endometrial stripe were divided into two groups based on the endometrial stripe thickness (>12 mm or ≤ 12 mm). All patients were candidates for single-dose methotrexate treatment. Variables analyzed between the two groups were endometrial stripe thickness, initial beta human chorionic gonadotropin level (hCG), size of the ectopic mass, presence of fetal heart tones, previous ectopic pregnancy, and clinical outcomes. Results: Sixty patients had endometrial stripe thickness ≤ 12 mm and 13 patients >12 mm. The two groups were similar in initial hCG, size of ectopic mass, presence of fetal heart tones and rate of previous ectopic pregnancy. The failure rate was significantly higher in the group with endometrial stripe >12 mm compared to the group ≤ 12 mm (n=7, 53% vs. n=3, 5%, P<0.01). The endometrial stripe was significantly thicker in the group with endometrial stripe thickness >12 mm compared to the group ≤ 12 mm (mean ± SD, 17.64±5.82 mm vs. 7.69±2.82 mm, P<0.01). Conclusion: Endometrial stripe thicker than 12 mm increases the risk for treatment failure with single-dose methotrexate.
KW - Ectopic pregnancy
KW - Endometrial stripe
KW - Methotrexate
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U2 - 10.1007/s00404-005-0009-y
DO - 10.1007/s00404-005-0009-y
M3 - Article
C2 - 16001188
AN - SCOPUS:26644470374
VL - 272
SP - 269
EP - 272
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
SN - 0932-0067
IS - 4
ER -