Abstract
Recent studies of rat and human calcitonin (CT) gene expression have uncovered a diversity of secretory peptides. Here we report the results of testing two such non-CT secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide, CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro experiments are consistent with the idea that CT gene-related peptide is acting at CT receptors in bone.
Original language | English (US) |
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Pages (from-to) | 46-51 |
Number of pages | 6 |
Journal | Endocrinology |
Volume | 118 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1986 |
ASJC Scopus subject areas
- Endocrinology