Evaluation of the in vivo and in vitro calcium regulating actions of noncalcitonin peptides produced via calcitonin gene expression

Bernard A. Roos, Jan A. Fischer, Werner Pignat, Cynthia B. Alander, Lawrence G. Raisz

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Recent studies of rat and human calcitonin (CT) gene expression have uncovered a diversity of secretory peptides. Here we report the results of testing two such non-CT secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide, CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro experiments are consistent with the idea that CT gene-related peptide is acting at CT receptors in bone.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalEndocrinology
Volume118
Issue number1
DOIs
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Endocrinology

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