Evaluation of the gonadotrophic responsiveness of the pituitary to acute and prolonged administration of LH/FSH-releasing hormone (LH-RH) in normal females and males

H. Pinto, L. Wajchenberg, F. B. Lima, J. Goldman, A. M. Comaru-Schally, A. V. Schally

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11 Scopus citations

Abstract

In normal females, the injection of 25 μg of LH-RH (acute test) induced a greater LH and FSH release from the pituitary in the mid-luteal than in the mid-follicular phase of the menstrual cycle. In normal males, the responsiveness to 25 μg LH-RH greater than that in females at midfollicular but not at the luteal stage. The pituitary response to the prolonged LH-RH infusion (0.21 μg/min/8 h) was similar in both phases of the cycle of the females with a decline in serum gonadotrophins after the 4th hour and was paralleled by a significant increase of plasma oestradiol levels. In males the LH, but not the FSH secretion was lower as compared to female subjects, and gonadotrophin levels did not show a fall during the infusion. The acute injection of 25 μg LH-RH at the end of a prolonged infusion induced the same response in the female subjects in both phases of the cycle. In males, the acute test following prolonged infusion produced a similar LH secretion, but a lower FSH response than in females. The comparison of the acute test alone and that preceded by a prolonged LH-RH infusion, demonstrated that, in females, the only significant differences consisted of a greater LH secretion in the former test in the mid-luteal phase. In males there was greater FSH secretion in the acute isolated test than when this test was given after the prolonged infusion.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalUnknown Journal
Volume91
Issue number1
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Endocrinology

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