Evaluation of the efficacy of acitretin therapy for nail psoriasis

Antonella Tosti, Carlos Ricotti, Paolo Romanelli, Norma Cameli, Bianca Maria Piraccini

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Objective: To evaluate the therapeutic efficacy of ac-itretin in patients with isolated nail psoriasis. Design: Open study involving 36 patients with moderate to severe nail psoriasis treated with acitretin. Setting: University-based outpatient dermatology clinic specializing in nail diseases. Patients: A total of 27 men and 9 women (mean age, 41 years) with nail psoriasis. Intervention: Therapy consisted of acitretin, 0.2 to 0.3 mg/kg/d, for 6 months. Main Outcome Measures: Clinical evaluation, and Nail Psoriasis Severity Index (NAPSI) and modified NAPSI scores before therapy, every 2 months during therapy, and 6 months after treatment. Results: The mean percentage of reduction of the NAPSI score after treatment was 41%; the mean percentage of reduction of the modified NAPSI score of the target nail was 50%. Clinical evaluation at 6 months showed complete or almost complete clearing of the nail lesions in 9 patients (25%), moderate improvement in 9 (25%), mild improvement in 12 (33%), and no improvement in 6 (11%). Conclusion: Results from low-dose acitretin therapy show NAPSI score reductions comparable with those studies evaluating biologic drugs for nail psoriasis and suggest that low-dose systemic acitretin should be considered in the treatment of nail psoriasis.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalArchives of Dermatology
Volume145
Issue number3
DOIs
StatePublished - Mar 1 2009

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Acitretin
Nails
Psoriasis
Therapeutics
Nail Diseases
Dermatology
Ambulatory Care Facilities

ASJC Scopus subject areas

  • Dermatology

Cite this

Evaluation of the efficacy of acitretin therapy for nail psoriasis. / Tosti, Antonella; Ricotti, Carlos; Romanelli, Paolo; Cameli, Norma; Piraccini, Bianca Maria.

In: Archives of Dermatology, Vol. 145, No. 3, 01.03.2009, p. 269-271.

Research output: Contribution to journalArticle

Tosti, Antonella ; Ricotti, Carlos ; Romanelli, Paolo ; Cameli, Norma ; Piraccini, Bianca Maria. / Evaluation of the efficacy of acitretin therapy for nail psoriasis. In: Archives of Dermatology. 2009 ; Vol. 145, No. 3. pp. 269-271.
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