Evaluation of the biological significance of leukocyte infiltration of the thyroid in Graves' disease

S. Levis, L. Ghandur-Mnaymneh, J. M. McKenzie, M. Zakarija

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Graves' goiter size and gland function may be affected by interferon-γ influencing actions of the thyroid-stimulating antibody. Goiter weight (n = 20), lymphocytic infiltration and class II antigen expression were assessed. The largest goiters, strikingly, has least infiltration but, overall, the looked-for negative correlation between goiter size and lymphocyte infiltration did not materialize. This was presumably due, in part, to inhibiting antibodies in many (8/18) patients' sera. In addition, our data do not support a major pathogenetic role for class II antigen in Graves' disease.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume99
Issue number1
DOIs
StatePublished - Jan 1 1992

Keywords

  • Autoimmunity
  • Graves' disease
  • Leukocyte infiltration
  • Thyroid

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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