Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain

F. Rousseau, Andrew A Maudsley, A. Ebel, A. Darkazanli, P. Weber, K. Sivasankaran, Y. Yu, C. Studholme

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

The implementation of Magnetic Resonance Spectroscopic Imaging (MRSI) for diagnostic imaging benefits from close integration of the lower-spatial resolution MRSI information with information from high-resolution structural MRI. Since patients can commonly move between acquisitions, it is necessary to account for possible mis-registration between the datasets arising from differences in patient positioning. In this paper we evaluate the use of 4 common multi-modality registration criteria to recover alignment between high resolution structural MRI and 3D MRSI data of the brain with sub-voxel accuracy. We explore the use of alternative MRSI water reference images to provide different types of structural information for the alignment process. The alignment accuracy was evaluated using both synthetically created MRSI and MRI data and a set of carefully collected subject image data with known ground truth spatial transformation between image volumes. The final accuracy and precision of estimates were assessed using multiple random starts of the registration algorithm. Sub voxel accuracy was found by all four similarity criteria with normalized mutual information providing the lowest target registration error for the 7 subject images. This effort supports the ongoing development of a database of brain metabolite distributions in normal subjects, which will be used in the evaluation of metabolic changes in neurological diseases.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsJ.M. Fitzpatrick, J.M. Reinhardt
Pages1213-1221
Number of pages9
Volume5747
EditionII
DOIs
StatePublished - 2005
EventMedical Imaging 2005 - Image Processing - San Diego, CA, United States
Duration: Feb 13 2005Feb 17 2005

Other

OtherMedical Imaging 2005 - Image Processing
CountryUnited States
CitySan Diego, CA
Period2/13/052/17/05

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Magnetic resonance imaging
Magnetic resonance
Brain
Spectroscopy
Imaging techniques
Metabolites
Water

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Rousseau, F., Maudsley, A. A., Ebel, A., Darkazanli, A., Weber, P., Sivasankaran, K., ... Studholme, C. (2005). Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. In J. M. Fitzpatrick, & J. M. Reinhardt (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (II ed., Vol. 5747, pp. 1213-1221). [137] https://doi.org/10.1117/12.596345

Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. / Rousseau, F.; Maudsley, Andrew A; Ebel, A.; Darkazanli, A.; Weber, P.; Sivasankaran, K.; Yu, Y.; Studholme, C.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / J.M. Fitzpatrick; J.M. Reinhardt. Vol. 5747 II. ed. 2005. p. 1213-1221 137.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rousseau, F, Maudsley, AA, Ebel, A, Darkazanli, A, Weber, P, Sivasankaran, K, Yu, Y & Studholme, C 2005, Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. in JM Fitzpatrick & JM Reinhardt (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II edn, vol. 5747, 137, pp. 1213-1221, Medical Imaging 2005 - Image Processing, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.596345
Rousseau F, Maudsley AA, Ebel A, Darkazanli A, Weber P, Sivasankaran K et al. Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. In Fitzpatrick JM, Reinhardt JM, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II ed. Vol. 5747. 2005. p. 1213-1221. 137 https://doi.org/10.1117/12.596345
Rousseau, F. ; Maudsley, Andrew A ; Ebel, A. ; Darkazanli, A. ; Weber, P. ; Sivasankaran, K. ; Yu, Y. ; Studholme, C. / Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / J.M. Fitzpatrick ; J.M. Reinhardt. Vol. 5747 II. ed. 2005. pp. 1213-1221
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