TY - JOUR
T1 - Evaluation of osteopontin expression in chronic wounds
T2 - A potential prognostic and therapeutic biomarker
AU - Chimento, S.
AU - Billero, V.
AU - Cavallin, L.
AU - Romanelli, M.
AU - Nadji, M.
AU - Romanelli, P.
N1 - Publisher Copyright:
© 2017 MA Healthcare Ltd.
PY - 2017/9
Y1 - 2017/9
N2 - Objective: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. Methods: This retrospective study included archived biopsies of chronic wounds from several aetiologies. Immunohistochemical staining and blind analysis of OPN expression were carried out. Results: We assessed biopsies from venous leg ulcers (n=5), diabetic foot ulcers (n=5), pyoderma gangrenosum (n=5), squamous cell carcinoma ulcers (n=4), and calciphylaxis ulcers (n=3). The data revealed that all these sets of chronic ulcers expressed high levels of OPN. Conclusion: This study provides strong histopathologic evidence that OPN expression is significantly increased in chronic wounds, suggesting that its upregulation could contribute to the exacerbated inflammation. Furthermore, further characterisation of the role of OPN in wound healing could aid the development of specific and efficient anti-OPN therapies for the treatment of chronic wounds.
AB - Objective: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. Methods: This retrospective study included archived biopsies of chronic wounds from several aetiologies. Immunohistochemical staining and blind analysis of OPN expression were carried out. Results: We assessed biopsies from venous leg ulcers (n=5), diabetic foot ulcers (n=5), pyoderma gangrenosum (n=5), squamous cell carcinoma ulcers (n=4), and calciphylaxis ulcers (n=3). The data revealed that all these sets of chronic ulcers expressed high levels of OPN. Conclusion: This study provides strong histopathologic evidence that OPN expression is significantly increased in chronic wounds, suggesting that its upregulation could contribute to the exacerbated inflammation. Furthermore, further characterisation of the role of OPN in wound healing could aid the development of specific and efficient anti-OPN therapies for the treatment of chronic wounds.
KW - Chronic wounds
KW - Non-healing ulcers
KW - Osteopontin
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85037057985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037057985&partnerID=8YFLogxK
U2 - 10.12968/jowc.2017.26.Sup9.S4
DO - 10.12968/jowc.2017.26.Sup9.S4
M3 - Article
C2 - 28880752
AN - SCOPUS:85037057985
VL - 26
SP - S4-S8
JO - Journal of wound care
JF - Journal of wound care
SN - 0969-0700
IS - 9
ER -