Evaluation of lenticonus in Alport's syndrome: Quantitative scheimpflug analysis

Wei Zhou, Marc Hirsch, Anna K. Junk, Daniel S. Casper, Richard Braunstein, Janice David, Basil V. Worgul

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Anterior lenticonus is an ocular abnormality that can occur in Alport's syndrome. In this study, Scheimpflug slit imaging analyses were employed for quantitative and objective evaluation of lens changes associated with Alport's syndrome. It was determined that while the apices of the lenticular protrusions are central in the vertical plane, they are nasally displaced in the horizontal meridian. The eccentricity and dimensions of the diameters and thicknesses of the conical aberration are highly correlated in both eyes. Lens thickness and anterior chamber depth do not differ between eyes. Densitometrically similar differences are apparent in the cortex and nuclear regions although evidence of overt opacification may or may not be present. The data strongly suggest that the physical parameters of the lenticonus are consistent with the constraints imposed by the pupil. Changes observed in the cornea and the vitreous may be associated with the syndrome.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
Issue number3
StatePublished - 2003
Externally publishedYes


  • Alport's syndrome
  • Biometry
  • Cataract
  • Cornea
  • Densitometry
  • Lens
  • Lenticonus
  • Quantitative assessment
  • Scheimpflug imaging
  • Vitreous

ASJC Scopus subject areas

  • Ophthalmology


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