Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data

Celina Imielinska, Yinpeng Jin, Xin Liu, Joel Rosiene, Brad E. Zacharia, Ricardo J. Komotar, J. Mocco, Michael E. Sughrue, Bartosz Grobelny, Alex Sisti, Josh Silverberg, Joyce Khandji, Hillary Cohen, Sander Connolly, Anthony L. D'Ambrosio

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

A segmentation method that quantifies cerebral infarct using rat data with ischemic stroke is evaluated using ground truth from histologic and MR data. To demonstrate alternative approach to rapid quantification of cerebral infarct volumes using histologic stained slices that requires scarifying animal life, a study with MR acquire volumetric rat data is proposed where ground truth is obtained by manual delineations by experts and automated segmentation is assessed for accuracy. A framework for evaluation of segmentation is used that provides more detailed accuracy measurements than mere cerebral infarct volume. Our preliminary experiment shows that ground truth derived from MRI data is at least as good as the one obtained from the histologic slices for evaluating segmentation algorithms for accuracy. Therefore we can develop and evaluate automated segmentation methods for rapid quantification of stroke without the necessitating animal sacrifice.

Original languageEnglish (US)
Article number201
Pages (from-to)1732-1741
Number of pages10
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5747
Issue numberIII
DOIs
StatePublished - Aug 25 2005
Externally publishedYes
EventMedical Imaging 2005 - Image Processing - San Diego, CA, United States
Duration: Feb 13 2005Feb 17 2005

Keywords

  • Magnetic resonance
  • Neurological
  • Quality
  • Segmentation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Imielinska, C., Jin, Y., Liu, X., Rosiene, J., Zacharia, B. E., Komotar, R. J., Mocco, J., Sughrue, M. E., Grobelny, B., Sisti, A., Silverberg, J., Khandji, J., Cohen, H., Connolly, S., & D'Ambrosio, A. L. (2005). Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5747(III), 1732-1741. [201]. https://doi.org/10.1117/12.596662