Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data

Celina Imielinska, Yinpeng Jin, Xin Liu, Joel Rosiene, Brad E. Zacharia, Ricardo J Komotar, J. Mocco, Michael E. Sughrue, Bartosz Grobelny, Alex Sisti, Josh Silverberg, Joyce Khandji, Hillary Cohen, Sander Connolly, Anthony L. D'Ambrosio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A segmentation method that quantifies cerebral infarct using rat data with ischemic stroke is evaluated using ground truth from histologic and MR data. To demonstrate alternative approach to rapid quantification of cerebral infarct volumes using histologic stained slices that requires scarifying animal life, a study with MR acquire volumetric rat data is proposed where ground truth is obtained by manual delineations by experts and automated segmentation is assessed for accuracy. A framework for evaluation of segmentation is used that provides more detailed accuracy measurements than mere cerebral infarct volume. Our preliminary experiment shows that ground truth derived from MRI data is at least as good as the one obtained from the histologic slices for evaluating segmentation algorithms for accuracy. Therefore we can develop and evaluate automated segmentation methods for rapid quantification of stroke without the necessitating animal sacrifice.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsJ.M. Fitzpatrick, J.M. Reinhardt
Pages1732-1741
Number of pages10
Volume5747
EditionIII
DOIs
StatePublished - 2005
Externally publishedYes
EventMedical Imaging 2005 - Image Processing - San Diego, CA, United States
Duration: Feb 13 2005Feb 17 2005

Other

OtherMedical Imaging 2005 - Image Processing
CountryUnited States
CitySan Diego, CA
Period2/13/052/17/05

Fingerprint

Rats
Animals
Magnetic resonance imaging
Experiments

Keywords

  • Magnetic resonance
  • Neurological
  • Quality
  • Segmentation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Imielinska, C., Jin, Y., Liu, X., Rosiene, J., Zacharia, B. E., Komotar, R. J., ... D'Ambrosio, A. L. (2005). Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. In J. M. Fitzpatrick, & J. M. Reinhardt (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (III ed., Vol. 5747, pp. 1732-1741). [201] https://doi.org/10.1117/12.596662

Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. / Imielinska, Celina; Jin, Yinpeng; Liu, Xin; Rosiene, Joel; Zacharia, Brad E.; Komotar, Ricardo J; Mocco, J.; Sughrue, Michael E.; Grobelny, Bartosz; Sisti, Alex; Silverberg, Josh; Khandji, Joyce; Cohen, Hillary; Connolly, Sander; D'Ambrosio, Anthony L.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / J.M. Fitzpatrick; J.M. Reinhardt. Vol. 5747 III. ed. 2005. p. 1732-1741 201.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Imielinska, C, Jin, Y, Liu, X, Rosiene, J, Zacharia, BE, Komotar, RJ, Mocco, J, Sughrue, ME, Grobelny, B, Sisti, A, Silverberg, J, Khandji, J, Cohen, H, Connolly, S & D'Ambrosio, AL 2005, Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. in JM Fitzpatrick & JM Reinhardt (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. III edn, vol. 5747, 201, pp. 1732-1741, Medical Imaging 2005 - Image Processing, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.596662
Imielinska C, Jin Y, Liu X, Rosiene J, Zacharia BE, Komotar RJ et al. Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. In Fitzpatrick JM, Reinhardt JM, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. III ed. Vol. 5747. 2005. p. 1732-1741. 201 https://doi.org/10.1117/12.596662
Imielinska, Celina ; Jin, Yinpeng ; Liu, Xin ; Rosiene, Joel ; Zacharia, Brad E. ; Komotar, Ricardo J ; Mocco, J. ; Sughrue, Michael E. ; Grobelny, Bartosz ; Sisti, Alex ; Silverberg, Josh ; Khandji, Joyce ; Cohen, Hillary ; Connolly, Sander ; D'Ambrosio, Anthony L. / Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / J.M. Fitzpatrick ; J.M. Reinhardt. Vol. 5747 III. ed. 2005. pp. 1732-1741
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