Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species

Kiichi Ishiwata, Kazunori Kawamura, Wei Fang Wang, Hideo Tsukada, Norihiro Harada, Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Ren Iwata, Kazuhiko Yanai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.

Original languageEnglish (US)
Pages (from-to)493-502
Number of pages10
JournalNuclear Medicine and Biology
Volume31
Issue number4
DOIs
StatePublished - May 1 2004
Externally publishedYes

Fingerprint

Doxepin
Histamine H1 Receptors
Chlorpheniramine
Positron-Emission Tomography
Haplorhini
Guinea Pigs
Rabbits
Brain

Keywords

  • [C]doxepin
  • Histamine H receptor
  • Positron emission tomography

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species. / Ishiwata, Kiichi; Kawamura, Kazunori; Wang, Wei Fang; Tsukada, Hideo; Harada, Norihiro; Mochizuki, Hideki; Kimura, Yuichi; Ishii, Kenji; Iwata, Ren; Yanai, Kazuhiko.

In: Nuclear Medicine and Biology, Vol. 31, No. 4, 01.05.2004, p. 493-502.

Research output: Contribution to journalArticle

Ishiwata, K, Kawamura, K, Wang, WF, Tsukada, H, Harada, N, Mochizuki, H, Kimura, Y, Ishii, K, Iwata, R & Yanai, K 2004, 'Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species', Nuclear Medicine and Biology, vol. 31, no. 4, pp. 493-502. https://doi.org/10.1016/j.nucmedbio.2003.11.005
Ishiwata, Kiichi ; Kawamura, Kazunori ; Wang, Wei Fang ; Tsukada, Hideo ; Harada, Norihiro ; Mochizuki, Hideki ; Kimura, Yuichi ; Ishii, Kenji ; Iwata, Ren ; Yanai, Kazuhiko. / Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species. In: Nuclear Medicine and Biology. 2004 ; Vol. 31, No. 4. pp. 493-502.
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