Abstract
The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 493-502 |
| Number of pages | 10 |
| Journal | Nuclear Medicine and Biology |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2004 |
| Externally published | Yes |
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Keywords
- [C]doxepin
- Histamine H receptor
- Positron emission tomography
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species. / Ishiwata, Kiichi; Kawamura, Kazunori; Wang, Wei Fang; Tsukada, Hideo; Harada, Norihiro; Mochizuki, Hideki; Kimura, Yuichi; Ishii, Kenji; Iwata, Ren; Yanai, Kazuhiko.
In: Nuclear Medicine and Biology, Vol. 31, No. 4, 01.05.2004, p. 493-502.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species
AU - Ishiwata, Kiichi
AU - Kawamura, Kazunori
AU - Wang, Wei Fang
AU - Tsukada, Hideo
AU - Harada, Norihiro
AU - Mochizuki, Hideki
AU - Kimura, Yuichi
AU - Ishii, Kenji
AU - Iwata, Ren
AU - Yanai, Kazuhiko
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.
AB - The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.
KW - [C]doxepin
KW - Histamine H receptor
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=11144354698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144354698&partnerID=8YFLogxK
U2 - 10.1016/j.nucmedbio.2003.11.005
DO - 10.1016/j.nucmedbio.2003.11.005
M3 - Article
C2 - 15093820
AN - SCOPUS:11144354698
VL - 31
SP - 493
EP - 502
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 4
ER -