TY - JOUR
T1 - Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species
AU - Ishiwata, Kiichi
AU - Kawamura, Kazunori
AU - Wang, Wei Fang
AU - Tsukada, Hideo
AU - Harada, Norihiro
AU - Mochizuki, Hideki
AU - Kimura, Yuichi
AU - Ishii, Kenji
AU - Iwata, Ren
AU - Yanai, Kazuhiko
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, and for Creative Scientific Research of Japan Society for the Promotion of Science.
PY - 2004/5
Y1 - 2004/5
N2 - The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.
AB - The specific binding of [11C]doxepin, which has been used as a radioligand for mapping histamine H1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [11C]doxepin uptake was reduced by treatment with cold doxepin and two H1 receptor antagonists, but not with H2/H3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig.
KW - Histamine H receptor
KW - Positron emission tomography
KW - [C]doxepin
UR - http://www.scopus.com/inward/record.url?scp=11144354698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144354698&partnerID=8YFLogxK
U2 - 10.1016/j.nucmedbio.2003.11.005
DO - 10.1016/j.nucmedbio.2003.11.005
M3 - Article
C2 - 15093820
AN - SCOPUS:11144354698
VL - 31
SP - 493
EP - 502
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 4
ER -