Evaluation of dementia rating scales in Parkinsongs disease dementia

Philip D. Harvey, Steven H. Ferris, Jeffrey L. Cummings, Keith A. Wesnes, Chuanchieh Hsu, Roger M. Lane, Sibel Tekin

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Disease-specific assessments are not currently available for patients with Parkinsongs disease dementia (PDD). This study evaluated the criterion-related validity and test-retest reliability of the Alzheimergs Disease Assessment scale cognitive subscale (ADAS-cog) in terms of sensitivity for differentiation between mild and moderate severity impairment in PDD. Six other dementia rating scales and cognitive tests were also examined. A total of 113 patients with PDD or Alzheimer disease were recruited into this 4-week, multicenter study, segregated into 2 severity groups based on Mini-Mental State Examination (MMSE) score. Mean ADAS-cog scores showed a statistically significant separation between mild and moderate severity patients in both dementias (P <.001). For the ADAS-cog, test-retest Spearman correlation coefficients were significant for each dementia type and severity. This study demonstrated the criterion-related validity and test-retest reliability for ADAS-cog in patients with PDD and strong correlations with MMSE. This supports the validity of previous results obtained with these measures in studies of patients with PDD.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume25
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

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Keywords

  • Dementia assessment scales
  • Parkinsongs disease dementia
  • Reliability
  • Validity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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