Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.

Original languageEnglish (US)
Pages (from-to)1798-1802
Number of pages5
JournalJournal of Infectious Diseases
Volume185
Issue number12
DOIs
StatePublished - Jun 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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