Dibromodulcitol was administered orally on Days 1-10 every 3-4 weeks to 29 patients with metastatic breast carcinoma refractory to previous combination chemotherapy. Initial doses between 70 and 280 mg/m 2/day were utilized. The dose was escalated as tolerated in subsequent cycles in individual patients. Hematosuppression was dose-limiting. At doses of <200 mg/m 2/day leukopenia (<1000 cells/mm 3) and thrombocytopenia (<25,000 platelets/mm 3) occurred in one of 28 cycles and two of 27 cycles respectively. In contrast, at doses of ≥200 mg/m 2/day leukopenia and thrombocytopenia occurred in four of 18 cycles and five of 18 cycles respectively. Recovery of leukocytes (>4000 cells/mm 3) and platelets (>100,000 platelets/mm 3) by Day 29 after the start of therapy was also delayed at higher doses. Responses were observed in three of 29 evaluable patients and subjective improvement of osseous disease in one additional patient. A dose of 180 mg/m 2/day x 10 every 28 days is recommended in previously treated patients to avoid severe hematologic side effects.
|Original language||English (US)|
|Number of pages||4|
|Journal||Cancer Treatment Reports|
|State||Published - Dec 1 1976|
ASJC Scopus subject areas
- Cancer Research