Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods

Mabel Enriquez-Algeciras, Di Ding, Tsung Han Chou, Jianhua Wang, Kyle Padgett, Vittorio Porciatti, Sanjoy K Bhattacharya

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE. To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods. METHODS. Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. RESULTS. Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/ behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities. CONCLUSIONS. The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.

Original languageEnglish
Pages (from-to)2405-2411
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number5
DOIs
StatePublished - Apr 1 2011

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Nervous System Malformations
Transgenic Mice
Multiple Sclerosis
Magnetic Resonance Imaging
Gait
Tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods. / Enriquez-Algeciras, Mabel; Ding, Di; Chou, Tsung Han; Wang, Jianhua; Padgett, Kyle; Porciatti, Vittorio; Bhattacharya, Sanjoy K.

In: Investigative Ophthalmology and Visual Science, Vol. 52, No. 5, 01.04.2011, p. 2405-2411.

Research output: Contribution to journalArticle

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AU - Bhattacharya, Sanjoy K

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