Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods

Mabel Enriquez-Algeciras, Di Ding, Tsung Han Chou, Jianhua Wang, Kyle R. Padgett, Vittorio Porciatti, Sanjoy K. Bhattacharya

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

PURPOSE. To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods. METHODS. Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. RESULTS. Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/ behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities. CONCLUSIONS. The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.

Original languageEnglish (US)
Pages (from-to)2405-2411
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number5
DOIs
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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