Evaluation and treatment of infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy

Federica Di Guardo, Luigi Della Corte, George Angelos Vilos, Jose Carugno, Péter Török, Pierluigi Giampaolino, Rahul Manchanda, Salvatore Giovanni Vitale

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Asherman syndrome is a rare acquired clinical condition resulting in the obliteration of the uterine cavity causedby the presence of partial or complete fibrous intrauterine adhesions involving at least two-thirds of the uterine cavity potentially obstructing the internal cervical orifice. Common reported symptoms of the disease are alterations of the menstrual pattern with decreased menstrual bleeding leading up to amenorrhoea and infertility. Hysteroscopy is currently considered the gold standard diagnostic and therapeutic approach for patients with intrauterine adhesions. An integrated approach, including preoperative, intraoperative and postoperative therapeutic measures, however, are warranted owing to the complexity of the syndrome. This review aims to summarize the most recent evidence on the recommended preoperative, intraoperative and postoperative procedures to restore the uterine cavity and a functional endometrium, as well as on the concomitant use of adjuvant therapies to achieve optimal fertility outcomes.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalReproductive BioMedicine Online
Issue number1
StatePublished - Jul 2020


  • Asherman's syndrome
  • Hysteroscopy
  • Infertility
  • Intrauterine adhesions
  • Synechiae

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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