Evaluation and management of lacrimal gland diseases

Research output: Chapter in Book/Report/Conference proceedingChapter


The lacrimal gland is the epicenter of a broad spectrum of neoplastic and inflammatory diseases (Table 58.1). Space occupying lesions of the lacrimal gland and its fossa constitute approximately 5–13% of orbital masses upon biopsy [1–3]. Based primarily on Reese's [4] 1956 clinicopathologic survey of 112 consecutive expanding lesions of the lacrimal gland, most authorities generally report that approximately 50% of the lesions originate from epithelial elements of the lacrimal gland and 50% are of non-epithelial origin [5–7]. Of non-epithelial lesions, 50% are lymphoid tumors and 50% are comprised of various infections and inflammatory pseudotumors. Among the epithelial tumors of the lacrimal gland, approximately 50% are pleomorphic adenomas (benign mixed tumors), 25% adenoid cystic carcinoma, and the remainders are other types of carcinoma. Recent reports, however, suggest that inflammatory lesions and lymphoid tumors are more common, and that epithelial malignancies of the lacrimal gland are considerably less frequent than commonly cited, ranging from 22% to 47% [1, 3, 7–10]. Proper differentiation between these two groups is of paramount importance since several of the lesions are life threatening.

Original languageEnglish (US)
Title of host publicationSmith and Nesi's Ophthalmic Plastic and Reconstructive Surgery, Third Edition
PublisherSpringer New York
Number of pages21
ISBN (Electronic)9781461409717
ISBN (Print)9781461409700
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)


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