Evaluating the impact of chronic obstructive pulmonary disease on in-hospital outcomes following left ventricular assist device implantation

Bertrand Ebner, Jelani K. Grant, Louis Vincent, Jennifer Maning, Neal Olarte, Odunayo Olorunfemi, Rosario Colombo, Sandra Chaparro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a cause of ventricular dysfunction. However, in the setting of patients with heart failure undergoing left ventricular assist device (LVAD) implantation, there is a paucity of data on the association between COPD and in-hospital outcomes. Methods and Results: Retrospective cohort study based on the NIS including patients ≥18 years who underwent LVAD implantation from 2011 to 2017. Multivariate regression was used to evaluate the impact of COPD on in-hospital outcomes. A total of 25,503 patients underwent LVAD implantation, of which 13.8% also had COPD. COPD group was older (median 62 vs. 58 years), and more males (82% vs. 76.4%, p <.001 for both). COPD group had more hypertension, diabetes, atrial tachyarrhythmias, dyslipidemia, prior stroke, coronary artery diseases, pulmonary hypertension, and chronic kidney disease (p <.001 for all). No differences in strokes, infections, mechanical circulatory support, and LVAD thrombosis. There was a higher incident of inpatient acute kidney injury, major bleeding, cardiac complications, thromboembolism, and cardiac arrest in patients without COPD (p <.05 for all). Compared with no-COPD group, COPD group had a lower mortality (6.2% vs. 12.4%; odds ratio, 0.59; confidence interval, 0.512–0.685; p <.05). Conclusion: Patients with COPD undergoing LVAD implantation have more comorbidities, without an associated increase mortality.

Original languageEnglish (US)
Pages (from-to)3374-3380
Number of pages7
JournalJournal of cardiac surgery
Volume35
Issue number12
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • advanced heart failure
  • mechanical circulatory support
  • pulmonary disease

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Evaluating the impact of chronic obstructive pulmonary disease on in-hospital outcomes following left ventricular assist device implantation'. Together they form a unique fingerprint.

Cite this