Evaluating the efficacy of L-N-acetylcysteine and dexamethasone in combination to provide otoprotection for electrode insertion trauma

Adrien A. Eshraghi, David Shahal, Camron Davies, Jeenu Mittal, Viraj Shah, Erdogan Bulut, Carolyn Garnham, Priyanka Sinha, Dibyanshi Mishra, Hannah Marwede, Rahul Mittal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Electrode insertion trauma (EIT) during cochlear implantation (CI) can cause loss of residual hearing. L-N-acetylcysteine (L-NAC) and dexamethasone (Dex) have been individually shown to provide otoprotection albeit at higher concentrations that may be associated with adverse effects. Objective/Aims: The aim of this study is to determine whether L-NAC and Dex could be combined to decrease their effective dosage. Materials and Methods: The organ of Corti (OC) explants were divided into various groups: 1) control; 2) EIT; 3) EIT treated with different concentrations of Dex; 4) EIT treated with different concentrations of L-NAC; 5) EIT treated with L-NAC and Dex in combination. Hair cell (HC) density, levels of oxidative stress, proinflammatory cytokines and nitric oxide (NO) was determined. Results: There was a significant loss of HCs in explants subjected to EIT compared to the control group. L-NAC and Dex in combination was able to provide significant otoprotection at lower concentrations compared to individual drugs. Conclusions and Significance: A combination containing L-NAC and Dex is effective in protecting sensory cells at lower protective doses than each compound separately. These compounds can be combined allowing a decrease of potential side effects of each compound and providing significant otoprotection for EIT.

Original languageEnglish (US)
Article number716
JournalJournal of Clinical Medicine
Volume9
Issue number3
DOIs
StatePublished - Mar 2020

Keywords

  • Dexamethasone
  • Electrode insertion trauma
  • L-N-acetylcysteine
  • Nitric oxide
  • Organ of Corti
  • Oxidative stress
  • Proinflammatory cytokines
  • Residual hearing

ASJC Scopus subject areas

  • Medicine(all)

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