Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping

D. D. Cyr, A. S. Allen, G. J. Du, F. Ruffin, C. Adams, J. T. Thaden, S. A. Maskarinec, M. Souli, S. Guo, Derek M Dykxhoorn, William K Scott, V. G. Fowler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ2(1df) score (MIX) to jointly evaluate both single-nucleotide polymorphism (SNP) and admixture association (P<5.00e-08) were computed using MIXSCORE. In addition, a permutation scheme was implemented to derive multiplicity adjusted P-values (genome-wide 0.05 significance threshold: P<9.46e-05). After empirical multiplicity adjustment, one region on chromosome 6 (52 SNPs, P=4.56e-05) in the HLA class II region was found to exhibit a genome-wide statistically significant increase in European ancestry. This region encodes genes involved in HLA-mediated immune response and these results provide additional evidence for genetic variation influencing HLA-mediated immunity, modulating susceptibility to SAB.Genes and Immunity advance online publication, 23 March 2017; doi:10.1038/gene.2017.6.

Original languageEnglish (US)
JournalGenes and Immunity
DOIs
StateAccepted/In press - Mar 23 2017

Fingerprint

Genetic Predisposition to Disease
Bacteremia
African Americans
Staphylococcus aureus
Genome
Single Nucleotide Polymorphism
Immunity
Chromosomes, Human, Pair 6
Genes
Publications
Incidence
Population

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Cyr, D. D., Allen, A. S., Du, G. J., Ruffin, F., Adams, C., Thaden, J. T., ... Fowler, V. G. (Accepted/In press). Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping. Genes and Immunity. https://doi.org/10.1038/gene.2017.6

Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping. / Cyr, D. D.; Allen, A. S.; Du, G. J.; Ruffin, F.; Adams, C.; Thaden, J. T.; Maskarinec, S. A.; Souli, M.; Guo, S.; Dykxhoorn, Derek M; Scott, William K; Fowler, V. G.

In: Genes and Immunity, 23.03.2017.

Research output: Contribution to journalArticle

Cyr, D. D. ; Allen, A. S. ; Du, G. J. ; Ruffin, F. ; Adams, C. ; Thaden, J. T. ; Maskarinec, S. A. ; Souli, M. ; Guo, S. ; Dykxhoorn, Derek M ; Scott, William K ; Fowler, V. G. / Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping. In: Genes and Immunity. 2017.
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