Euxyl K 400: A new sensitizer in cosmetics

Antonella Tosti, L. Guerra, F. Bardazzi, F. Gasparri

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Euxyl K 400 is a preservative for cosmetics and toiletries containing 2 active ingredients, 1,2-dibromo-2,4-dicyanobutan and 2-phenoxyethanol. 2057 consecutive patients with contact dermatitis were patch tested with Euxyl K 400 2.5% pet. and ethanol. A positive patch test occurred in 24 patients (1.2%). The source of sensitization was traced in 8 patients to their cosmetics. Both leave-on and rinse-off products were responsible. Further patch tests with Euxyl K 400 0.5% pet. and phenoxyethanol 5% pet. were performed in 11 patients. A positive patch test to phenoxyethanol was detected in 1 of them. Only 3 patients showed a mild reaction to Euxyl K 400 0.5%. A provocative use test with a lotion preserved with Euxyl K 400 0.1% was positive in 5 of these 11 patients. Patients with Euxyl K 400 sensitivity showed a high prevalence of positive patch tests to other common ingredients of cosmetics. Since the use of Euxyl K 400 in cosmetic products is rapidly increasing, it should be included in the patch test series for patients with suspected cosmetic allergy.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalContact Dermatitis
Volume25
Issue number2
StatePublished - Aug 29 1991
Externally publishedYes

Fingerprint

Cosmetics
Patch Tests
Pets
Dermatitis
Allergies
1,2-dibromo-2,4-dicyanobutane
Contact Dermatitis
Ethanol
Hypersensitivity
phenoxyethanol

Keywords

  • 1,2-dibromo-dicyanobutan
  • 2-phenoxyethanol
  • cosmetic products
  • Euxyl K 400
  • patch testing
  • preservatives

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

Cite this

Tosti, A., Guerra, L., Bardazzi, F., & Gasparri, F. (1991). Euxyl K 400: A new sensitizer in cosmetics. Contact Dermatitis, 25(2), 89-93.

Euxyl K 400 : A new sensitizer in cosmetics. / Tosti, Antonella; Guerra, L.; Bardazzi, F.; Gasparri, F.

In: Contact Dermatitis, Vol. 25, No. 2, 29.08.1991, p. 89-93.

Research output: Contribution to journalArticle

Tosti, A, Guerra, L, Bardazzi, F & Gasparri, F 1991, 'Euxyl K 400: A new sensitizer in cosmetics', Contact Dermatitis, vol. 25, no. 2, pp. 89-93.
Tosti A, Guerra L, Bardazzi F, Gasparri F. Euxyl K 400: A new sensitizer in cosmetics. Contact Dermatitis. 1991 Aug 29;25(2):89-93.
Tosti, Antonella ; Guerra, L. ; Bardazzi, F. ; Gasparri, F. / Euxyl K 400 : A new sensitizer in cosmetics. In: Contact Dermatitis. 1991 ; Vol. 25, No. 2. pp. 89-93.
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