EUS-guided fine needle aspiration of the liver

Indications, yield, and safety based on an international survey of 167 cases

Jorgen TenBerge, Brenda J. Hoffman, Robert H. Hawes, Conny Van Enckevort, Marc Giovannini, Richard A. Erickson, Marc F. Catalano, Roberto Fogel, Shawn Mallery, Douglas O. Faigel, Angelo P. Ferrari, Irving Waxman, Larent Palazzo, Tamir Ben-Menachem, Paul S. Jowell, Kevin M. McGrath, Thomas E. Kowalski, Cuong C. Nguyen, Wahid Y. Wassef, Keiji Yamao & 6 others Amitabh Chak, Bruce D. Greenwald, Timothy A. Woodward, Peter Vilmann, Luis Sabbagh, Michael B. Wallace

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Background: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers. Methods: A retrospective questionnaire was sent by e-mail to 130 EUS-FNA centers around the world regarding indications, complications, and findings of EUS-FNA of the liver. Results: Twenty-one centers reported 167 cases of EUS-FNA of the liver. A complication was reported in 6 (4%) of 167 cases including the following: death in 1 patient with an occluding biliary stent and biliary sepsis, bleeding (1), fever (2), and pain (2). EUS-FNA diagnosed malignancy in 23 of 26 (89%) cases after nondiagnostic fine needle aspiration under transabdominal US guidance. EUS localized an unrecognized primary tumor in 17 of 33 (52%) cases in which CT had demonstrated only liver metastases. EUS image characteristics were not predictive of malignant versus benign lesions. Conclusion: EUS-guided FNA of the liver appears to be a safe procedure with a major complication rate of approximately 1%. EUS-FNA should be considered when a liver lesion is poorly accessible to US-, or CT-guided FNA should be considered when US- or CT-guided FNA fail to make a diagnosis, when a liver lesion(s) is detected (de novo) by EUS, and for investigation of possible upper GI primary tumors in the setting of liver metastases.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalGastrointestinal Endoscopy
Volume55
Issue number7
DOIs
StatePublished - Jun 2002
Externally publishedYes

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Fine Needle Biopsy
Safety
Liver
Neoplasm Metastasis
Neoplasms
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Surveys and Questionnaires
Postal Service
Stents
Sepsis
Fever
Hemorrhage
Pain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

TenBerge, J., Hoffman, B. J., Hawes, R. H., Van Enckevort, C., Giovannini, M., Erickson, R. A., ... Wallace, M. B. (2002). EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases. Gastrointestinal Endoscopy, 55(7), 859-862. https://doi.org/10.1067/mge.2002.124557

EUS-guided fine needle aspiration of the liver : Indications, yield, and safety based on an international survey of 167 cases. / TenBerge, Jorgen; Hoffman, Brenda J.; Hawes, Robert H.; Van Enckevort, Conny; Giovannini, Marc; Erickson, Richard A.; Catalano, Marc F.; Fogel, Roberto; Mallery, Shawn; Faigel, Douglas O.; Ferrari, Angelo P.; Waxman, Irving; Palazzo, Larent; Ben-Menachem, Tamir; Jowell, Paul S.; McGrath, Kevin M.; Kowalski, Thomas E.; Nguyen, Cuong C.; Wassef, Wahid Y.; Yamao, Keiji; Chak, Amitabh; Greenwald, Bruce D.; Woodward, Timothy A.; Vilmann, Peter; Sabbagh, Luis; Wallace, Michael B.

In: Gastrointestinal Endoscopy, Vol. 55, No. 7, 06.2002, p. 859-862.

Research output: Contribution to journalArticle

TenBerge, J, Hoffman, BJ, Hawes, RH, Van Enckevort, C, Giovannini, M, Erickson, RA, Catalano, MF, Fogel, R, Mallery, S, Faigel, DO, Ferrari, AP, Waxman, I, Palazzo, L, Ben-Menachem, T, Jowell, PS, McGrath, KM, Kowalski, TE, Nguyen, CC, Wassef, WY, Yamao, K, Chak, A, Greenwald, BD, Woodward, TA, Vilmann, P, Sabbagh, L & Wallace, MB 2002, 'EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases', Gastrointestinal Endoscopy, vol. 55, no. 7, pp. 859-862. https://doi.org/10.1067/mge.2002.124557
TenBerge, Jorgen ; Hoffman, Brenda J. ; Hawes, Robert H. ; Van Enckevort, Conny ; Giovannini, Marc ; Erickson, Richard A. ; Catalano, Marc F. ; Fogel, Roberto ; Mallery, Shawn ; Faigel, Douglas O. ; Ferrari, Angelo P. ; Waxman, Irving ; Palazzo, Larent ; Ben-Menachem, Tamir ; Jowell, Paul S. ; McGrath, Kevin M. ; Kowalski, Thomas E. ; Nguyen, Cuong C. ; Wassef, Wahid Y. ; Yamao, Keiji ; Chak, Amitabh ; Greenwald, Bruce D. ; Woodward, Timothy A. ; Vilmann, Peter ; Sabbagh, Luis ; Wallace, Michael B. / EUS-guided fine needle aspiration of the liver : Indications, yield, and safety based on an international survey of 167 cases. In: Gastrointestinal Endoscopy. 2002 ; Vol. 55, No. 7. pp. 859-862.
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abstract = "Background: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers. Methods: A retrospective questionnaire was sent by e-mail to 130 EUS-FNA centers around the world regarding indications, complications, and findings of EUS-FNA of the liver. Results: Twenty-one centers reported 167 cases of EUS-FNA of the liver. A complication was reported in 6 (4{\%}) of 167 cases including the following: death in 1 patient with an occluding biliary stent and biliary sepsis, bleeding (1), fever (2), and pain (2). EUS-FNA diagnosed malignancy in 23 of 26 (89{\%}) cases after nondiagnostic fine needle aspiration under transabdominal US guidance. EUS localized an unrecognized primary tumor in 17 of 33 (52{\%}) cases in which CT had demonstrated only liver metastases. EUS image characteristics were not predictive of malignant versus benign lesions. Conclusion: EUS-guided FNA of the liver appears to be a safe procedure with a major complication rate of approximately 1{\%}. EUS-FNA should be considered when a liver lesion is poorly accessible to US-, or CT-guided FNA should be considered when US- or CT-guided FNA fail to make a diagnosis, when a liver lesion(s) is detected (de novo) by EUS, and for investigation of possible upper GI primary tumors in the setting of liver metastases.",
author = "Jorgen TenBerge and Hoffman, {Brenda J.} and Hawes, {Robert H.} and {Van Enckevort}, Conny and Marc Giovannini and Erickson, {Richard A.} and Catalano, {Marc F.} and Roberto Fogel and Shawn Mallery and Faigel, {Douglas O.} and Ferrari, {Angelo P.} and Irving Waxman and Larent Palazzo and Tamir Ben-Menachem and Jowell, {Paul S.} and McGrath, {Kevin M.} and Kowalski, {Thomas E.} and Nguyen, {Cuong C.} and Wassef, {Wahid Y.} and Keiji Yamao and Amitabh Chak and Greenwald, {Bruce D.} and Woodward, {Timothy A.} and Peter Vilmann and Luis Sabbagh and Wallace, {Michael B.}",
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T1 - EUS-guided fine needle aspiration of the liver

T2 - Indications, yield, and safety based on an international survey of 167 cases

AU - TenBerge, Jorgen

AU - Hoffman, Brenda J.

AU - Hawes, Robert H.

AU - Van Enckevort, Conny

AU - Giovannini, Marc

AU - Erickson, Richard A.

AU - Catalano, Marc F.

AU - Fogel, Roberto

AU - Mallery, Shawn

AU - Faigel, Douglas O.

AU - Ferrari, Angelo P.

AU - Waxman, Irving

AU - Palazzo, Larent

AU - Ben-Menachem, Tamir

AU - Jowell, Paul S.

AU - McGrath, Kevin M.

AU - Kowalski, Thomas E.

AU - Nguyen, Cuong C.

AU - Wassef, Wahid Y.

AU - Yamao, Keiji

AU - Chak, Amitabh

AU - Greenwald, Bruce D.

AU - Woodward, Timothy A.

AU - Vilmann, Peter

AU - Sabbagh, Luis

AU - Wallace, Michael B.

PY - 2002/6

Y1 - 2002/6

N2 - Background: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers. Methods: A retrospective questionnaire was sent by e-mail to 130 EUS-FNA centers around the world regarding indications, complications, and findings of EUS-FNA of the liver. Results: Twenty-one centers reported 167 cases of EUS-FNA of the liver. A complication was reported in 6 (4%) of 167 cases including the following: death in 1 patient with an occluding biliary stent and biliary sepsis, bleeding (1), fever (2), and pain (2). EUS-FNA diagnosed malignancy in 23 of 26 (89%) cases after nondiagnostic fine needle aspiration under transabdominal US guidance. EUS localized an unrecognized primary tumor in 17 of 33 (52%) cases in which CT had demonstrated only liver metastases. EUS image characteristics were not predictive of malignant versus benign lesions. Conclusion: EUS-guided FNA of the liver appears to be a safe procedure with a major complication rate of approximately 1%. EUS-FNA should be considered when a liver lesion is poorly accessible to US-, or CT-guided FNA should be considered when US- or CT-guided FNA fail to make a diagnosis, when a liver lesion(s) is detected (de novo) by EUS, and for investigation of possible upper GI primary tumors in the setting of liver metastases.

AB - Background: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers. Methods: A retrospective questionnaire was sent by e-mail to 130 EUS-FNA centers around the world regarding indications, complications, and findings of EUS-FNA of the liver. Results: Twenty-one centers reported 167 cases of EUS-FNA of the liver. A complication was reported in 6 (4%) of 167 cases including the following: death in 1 patient with an occluding biliary stent and biliary sepsis, bleeding (1), fever (2), and pain (2). EUS-FNA diagnosed malignancy in 23 of 26 (89%) cases after nondiagnostic fine needle aspiration under transabdominal US guidance. EUS localized an unrecognized primary tumor in 17 of 33 (52%) cases in which CT had demonstrated only liver metastases. EUS image characteristics were not predictive of malignant versus benign lesions. Conclusion: EUS-guided FNA of the liver appears to be a safe procedure with a major complication rate of approximately 1%. EUS-FNA should be considered when a liver lesion is poorly accessible to US-, or CT-guided FNA should be considered when US- or CT-guided FNA fail to make a diagnosis, when a liver lesion(s) is detected (de novo) by EUS, and for investigation of possible upper GI primary tumors in the setting of liver metastases.

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