Eukaryotic checkpoints are absent in the cell division cycle of Entamoeba histolytica

Sulagna Banerjee, Suchismita Das, Anuradha Lohia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Fidelity in transmission of genetic characters is ensured by the faithful duplication of the genome, followed by equal segregation of the genetic material in the progeny. Thus, alternation of DNA duplication (S-phase) and chromosome segregation during the M-phase are hallmarks of most well studied eukaryotes. Several rounds of genome reduplication before chromosome segregation upsets this cycle and leads to polyploidy. Polyploidy is often witnessed in cells prior to differentiation, in embryonic cells or in diseases such as cancer. Studies on the protozoan parasite, Entamoeba histolytica suggest that in its proliferative phase, this organism may accumulate polyploid cells. It has also been shown that although this organism contains sequence homologs of genes which are known to control the cell cycle of most eukaryotes, these genes may be structurally altered and their equivalent function yet to be demonstrated in amoeba. The available information suggests that surveillance mechanisms or 'checkpoints' which are known to regulate the eukaryotic cell cycle may be absent or altered in E. histolytica.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalJournal of Biosciences
Volume27
Issue number6 SUPPL. 3
DOIs
StatePublished - Nov 2002
Externally publishedYes

Keywords

  • Cell division cycle
  • Checkpoints
  • Entamoeba histolytica
  • Genome reduplication
  • Polyploidy
  • Protozoan parasite

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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