Etiology of Waldenström Macroglobulinemia: Genetic Factors and Immune-related Conditions

Elisabet E. Manasanch, Sigurdur Y. Kristinsson, Ola Landgren

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalClinical Lymphoma, Myeloma and Leukemia
Volume13
Issue number2
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • Autoimmune disease
  • Familial aggregation
  • Immune-related
  • MYD88 L265P
  • Susceptibility

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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