Etiology of autism: Genetic influences

S. E. Folstein, J. Piven

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

In summary, there are a few specific genetic conditions that can be associated with autism. Among cases of unknown etiology, there is ample evidence for a higher genetic liability to autism in siblings of autistic probands than expected from the population prevalence. It appears likely that both parents and siblings have a higher liability for social and cognitive deficits that are milder but conceptually similar to those found in autism. Others factors may alter this underlying genetic liability such as sex, IQ, and prenatal and perinatal injury. In the future, genetic analyses and genetic linkage studies will need to consider using a broader definition of the autism phenotype to include not only autism but severe cognitive and social deficits. The exact genetic mechanisms and genes involved are the subject of current investigations by several research groups. Investigations in this area are likely to continue to provide important information about the causes of autism.

Original languageEnglish
Pages (from-to)767-773
Number of pages7
JournalPediatrics
Volume87
Issue number5 II SUPPL.
StatePublished - Jan 1 1991

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Autistic Disorder
Prenatal Injuries
Genetic Linkage
Phenotype
Research
Population
Genes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Folstein, S. E., & Piven, J. (1991). Etiology of autism: Genetic influences. Pediatrics, 87(5 II SUPPL.), 767-773.

Etiology of autism : Genetic influences. / Folstein, S. E.; Piven, J.

In: Pediatrics, Vol. 87, No. 5 II SUPPL., 01.01.1991, p. 767-773.

Research output: Contribution to journalArticle

Folstein, SE & Piven, J 1991, 'Etiology of autism: Genetic influences', Pediatrics, vol. 87, no. 5 II SUPPL., pp. 767-773.
Folstein SE, Piven J. Etiology of autism: Genetic influences. Pediatrics. 1991 Jan 1;87(5 II SUPPL.):767-773.
Folstein, S. E. ; Piven, J. / Etiology of autism : Genetic influences. In: Pediatrics. 1991 ; Vol. 87, No. 5 II SUPPL. pp. 767-773.
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