Abstract
The underlying causes of 35 children with primary congenital hypothyroidism at the Children's Hospital were studied. There were 21 girls and 14 boys. Serum T4 and TSH level, 24 hours 131I uptake, and technetium-99m thyroid scintigraphy were performed after discontinuation of synthetic thyroid hormone for 4-6 weeks. Athyrosis was the most common cause and accounted for forty-three per cent of the patients. Twenty per cent of the patients had thyroid hypoplasia. Ectopic thyroid was found in thirty-three per cent of the patients. Only a patient whose diagnosis was organification defect had slightly enlarged thyroid gland, high retention of 131I and positive perchlorate discharge test. Onset of symptoms before 9 months of age may be helpful for distinguishing between lingual thyroid and the others. Serum T4 level less than 2 μg/dL was observed to be more common in athyrosis and lingual thyroid groups than thyroid hypoplasia group.
| Original language | English |
|---|---|
| Journal | Journal of the Medical Association of Thailand |
| Volume | 81 |
| Issue number | 9 |
| State | Published - Sep 1 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Etiologic Study of Primary Congenital Hypothyroidism. / Seeherunvong, Tossaporn; Churesigaew, Sunchai.
In: Journal of the Medical Association of Thailand, Vol. 81, No. 9, 01.09.1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Etiologic Study of Primary Congenital Hypothyroidism
AU - Seeherunvong, Tossaporn
AU - Churesigaew, Sunchai
PY - 1998/9/1
Y1 - 1998/9/1
N2 - The underlying causes of 35 children with primary congenital hypothyroidism at the Children's Hospital were studied. There were 21 girls and 14 boys. Serum T4 and TSH level, 24 hours 131I uptake, and technetium-99m thyroid scintigraphy were performed after discontinuation of synthetic thyroid hormone for 4-6 weeks. Athyrosis was the most common cause and accounted for forty-three per cent of the patients. Twenty per cent of the patients had thyroid hypoplasia. Ectopic thyroid was found in thirty-three per cent of the patients. Only a patient whose diagnosis was organification defect had slightly enlarged thyroid gland, high retention of 131I and positive perchlorate discharge test. Onset of symptoms before 9 months of age may be helpful for distinguishing between lingual thyroid and the others. Serum T4 level less than 2 μg/dL was observed to be more common in athyrosis and lingual thyroid groups than thyroid hypoplasia group.
AB - The underlying causes of 35 children with primary congenital hypothyroidism at the Children's Hospital were studied. There were 21 girls and 14 boys. Serum T4 and TSH level, 24 hours 131I uptake, and technetium-99m thyroid scintigraphy were performed after discontinuation of synthetic thyroid hormone for 4-6 weeks. Athyrosis was the most common cause and accounted for forty-three per cent of the patients. Twenty per cent of the patients had thyroid hypoplasia. Ectopic thyroid was found in thirty-three per cent of the patients. Only a patient whose diagnosis was organification defect had slightly enlarged thyroid gland, high retention of 131I and positive perchlorate discharge test. Onset of symptoms before 9 months of age may be helpful for distinguishing between lingual thyroid and the others. Serum T4 level less than 2 μg/dL was observed to be more common in athyrosis and lingual thyroid groups than thyroid hypoplasia group.
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UR - http://www.scopus.com/inward/citedby.url?scp=17144447218&partnerID=8YFLogxK
M3 - Article
C2 - 9737121
AN - SCOPUS:17144447218
VL - 81
JO - Journal of the Medical Association of Thailand
JF - Journal of the Medical Association of Thailand
SN - 0125-2208
IS - 9
ER -