Etiologic evaluation of male pseudohermaphroditism in infancy and childhood

Gary Berkovitz, P. A. Lee, T. R. Brown, C. J. Migeon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We outlined a diagnostic scheme for use with prepubertal patients with male pseudohermaphroditism (MPH) that included karyotyping, a genitourethrogram, a human chorionic gonadotropin stimulation test with plasma hormone level determinations, and determination of 5α-reductase activity and androgen receptor binding in genital skin fibroblasts. A thorough evaluation is warranted in all patients since the correct diagnosis may assist in determining gender assignment and providing appropriate genetic counseling. We studied 25 patients by the prescribed diagnostic scheme: seven of them had a partial gonadal dysgenesis, two were deficient in 5α-reductase activity, two showed partial androgen insensitivity, four had multiple congenital malformations, one had a Wilms' tumor, and nine were considered as having an idiopathic form of MPH.

Original languageEnglish
Pages (from-to)755-759
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume138
Issue number8
StatePublished - Jan 1 1984
Externally publishedYes

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XY Disorders of Sex Development 46
Oxidoreductases
Gonadal Dysgenesis
Androgen-Insensitivity Syndrome
Karyotyping
Wilms Tumor
Genetic Counseling
Androgen Receptors
Chorionic Gonadotropin
Fibroblasts
Hormones
Skin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Etiologic evaluation of male pseudohermaphroditism in infancy and childhood. / Berkovitz, Gary; Lee, P. A.; Brown, T. R.; Migeon, C. J.

In: American Journal of Diseases of Children, Vol. 138, No. 8, 01.01.1984, p. 755-759.

Research output: Contribution to journalArticle

Berkovitz, Gary ; Lee, P. A. ; Brown, T. R. ; Migeon, C. J. / Etiologic evaluation of male pseudohermaphroditism in infancy and childhood. In: American Journal of Diseases of Children. 1984 ; Vol. 138, No. 8. pp. 755-759.
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