Etiologic diagnosis of sensorineural hearing loss in adults

Simon I. Angeli, Denise Yan, Fred Telischi, Thomas J. Balkany, Xiao M. Ouyang, Li L. Du, Adrian Eshraghi, Leslie Goodwin, Xue Z. Liu

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


OBJECTIVE: To determine the etiology of adult-onset sensorineural hearing loss. STUDY DESIGN AND SETTING: This is a prospective cohort study of 60 adult subjects with bilateral sensorineural hearing loss of no obvious etiology by medical history and physical examination. These patients were evaluated at an academic medical center and underwent evaluation by high-resolution computed tomography of the temporal bone, autoimmune panel, and DNA testing for mutations of both the GJB2 gene and the mitochondrial DNA (1555A>G and 7445A>G). RESULTS: An etiologic diagnosis was achieved in 6 patients: cochlear otosclerosis, 1 case; dilated vestibular aqueduct, 1 case; a mitochondrial DNA 7445A>G mutation, 3 cases; and a mitochondrial DNA 1555A>G mutation, 1 case. CONCLUSION: This result underscores the importance of a search for the etiology of a hearing deficit in adult patients. There are specific interventions now available for the management of hearing-impaired patients with cochlear otosclerosis and mitochondrial DNA mutations.

Original languageEnglish (US)
Pages (from-to)890-895
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Issue number6
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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