TY - JOUR
T1 - Ethnic segregation of HTLV‐I and HTLV‐II carriers among South American native Indians
AU - Fujiyoshi, Toshinobu
AU - Yashiki, Shinji
AU - Fujiyama, Chihaya
AU - Kuwayama, Masahiro
AU - Miyashita, Hiroki
AU - Ohnishi, Hiroshi
AU - Blank, Michelle
AU - Zaninovic, Vladimir
AU - Blank, Abraham
AU - Cartier, Luis
AU - Byrnes, John J.
AU - Harrington, William J.
AU - Miura, Tomoyuki
AU - Hayami, Masanori
AU - Tajima, Kazuo
AU - Sonoda, Shunro
PY - 1995/11/15
Y1 - 1995/11/15
N2 - To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRBI*-DQBI* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-l-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.
AB - To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRBI*-DQBI* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-l-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.
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U2 - 10.1002/ijc.2910630409
DO - 10.1002/ijc.2910630409
M3 - Article
C2 - 7591259
AN - SCOPUS:0028823150
VL - 63
SP - 510
EP - 515
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 4
ER -