Ethnic segregation of HTLV‐I and HTLV‐II carriers among South American native Indians

Toshinobu Fujiyoshi, Shinji Yashiki, Chihaya Fujiyama, Masahiro Kuwayama, Hiroki Miyashita, Hiroshi Ohnishi, Michelle Blank, Vladimir Zaninovic, Abraham Blank, Luis Cartier, John J. Byrnes, William J. Harrington, Tomoyuki Miura, Masanori Hayami, Kazuo Tajima, Shunro Sonoda

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18 Scopus citations

Abstract

To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRBI*-DQBI* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-l-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalInternational Journal of Cancer
Volume63
Issue number4
DOIs
StatePublished - Nov 15 1995

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fujiyoshi, T., Yashiki, S., Fujiyama, C., Kuwayama, M., Miyashita, H., Ohnishi, H., Blank, M., Zaninovic, V., Blank, A., Cartier, L., Byrnes, J. J., Harrington, W. J., Miura, T., Hayami, M., Tajima, K., & Sonoda, S. (1995). Ethnic segregation of HTLV‐I and HTLV‐II carriers among South American native Indians. International Journal of Cancer, 63(4), 510-515. https://doi.org/10.1002/ijc.2910630409