Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians

T. Fujiyoshi, S. Yashiki, C. Fujiyama, M. Kuwayama, H. Miyashita, H. Ohnishi, M. Blank, V. Zaninovic, A. Blank, L. Cartier, John Byrnes, W. J. Harrington, T. Miura, M. Hayami, K. Tajima, S. Sonoda

Research output: Contribution to journalArticle

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Abstract

To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRBI*-DQBI* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-l-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalInternational Journal of Cancer
Volume63
Issue number4
DOIs
StatePublished - Dec 27 1995

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South American Indians
Human T-lymphotropic virus 2
Human T-lymphotropic virus 1
Haplotypes
North American Indians
HTLV-II Infections
HTLV-I Infections
Hantavirus
Population Groups
Restriction Fragment Length Polymorphisms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fujiyoshi, T., Yashiki, S., Fujiyama, C., Kuwayama, M., Miyashita, H., Ohnishi, H., ... Sonoda, S. (1995). Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. International Journal of Cancer, 63(4), 510-515. https://doi.org/10.1002/ijc.2910630409

Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. / Fujiyoshi, T.; Yashiki, S.; Fujiyama, C.; Kuwayama, M.; Miyashita, H.; Ohnishi, H.; Blank, M.; Zaninovic, V.; Blank, A.; Cartier, L.; Byrnes, John; Harrington, W. J.; Miura, T.; Hayami, M.; Tajima, K.; Sonoda, S.

In: International Journal of Cancer, Vol. 63, No. 4, 27.12.1995, p. 510-515.

Research output: Contribution to journalArticle

Fujiyoshi, T, Yashiki, S, Fujiyama, C, Kuwayama, M, Miyashita, H, Ohnishi, H, Blank, M, Zaninovic, V, Blank, A, Cartier, L, Byrnes, J, Harrington, WJ, Miura, T, Hayami, M, Tajima, K & Sonoda, S 1995, 'Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians', International Journal of Cancer, vol. 63, no. 4, pp. 510-515. https://doi.org/10.1002/ijc.2910630409
Fujiyoshi T, Yashiki S, Fujiyama C, Kuwayama M, Miyashita H, Ohnishi H et al. Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. International Journal of Cancer. 1995 Dec 27;63(4):510-515. https://doi.org/10.1002/ijc.2910630409
Fujiyoshi, T. ; Yashiki, S. ; Fujiyama, C. ; Kuwayama, M. ; Miyashita, H. ; Ohnishi, H. ; Blank, M. ; Zaninovic, V. ; Blank, A. ; Cartier, L. ; Byrnes, John ; Harrington, W. J. ; Miura, T. ; Hayami, M. ; Tajima, K. ; Sonoda, S. / Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. In: International Journal of Cancer. 1995 ; Vol. 63, No. 4. pp. 510-515.
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AU - Ohnishi, H.

AU - Blank, M.

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AU - Cartier, L.

AU - Byrnes, John

AU - Harrington, W. J.

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AU - Hayami, M.

AU - Tajima, K.

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