Ethnic differences in carotid artery diameter and stiffness: The Northern Manhattan Study

Matthew S. Markert, David Della Morte, Digna Cabral, Eugene L Roberts, Hannah Gardener, Chuanhui Dong, Clinton B Wright, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Race/ethnic differences in carotid arterial function and structure exist among those with cerebrovascular disease, but whether differences persist among healthy populations is unknown. Our objective was to investigate differences in carotid artery diameter and stiffness between race/ethnic groups, and examine whether these race/ethnic differences were age-dependent. Methods: Carotid diameters were assessed by B-mode ultrasound among 1536 participants from the Northern Manhattan Study (NOMAS), and carotid stiffness metrics were calculated. We used multivariable linear regression models to determine the relationship between race/ethnicity and both carotid arterial stiffness and carotid diastolic diameter. Results: Mean participant age was 70 ± 9 years (Hispanics = 68 ± 8, blacks = 72 ± 9, and whites = 74 ± 9, p< 0.0001). Mean DDIAM was 6.2 ± 1.0. mm (Hispanics = 6.2 ± 0.9 mm, blacks = 6.3 ± 1.0. mm, and whites = 6.3 ± 1.0. mm, p< 0.005) and mean STIFF was 8.7 ± 6.3 (Hispanics = 8.5 ± 5.7, blacks = 9.2 ± 6.2 and whites = 8.9 ± 6.9, p< 0.02). In a model that adjusted for sociodemographics and vascular risk factors including hypertension, diabetes, dislipidemia, renal function, physical acticity and a history of known coronary artery diseases; age was positively associated with greater DDIAM in Hispanics (p< 0.0001) but not among blacks or whites. Older age was associated with greater stiffness among Hispanics (p< 0.0001) and blacks (p< 0.003), but not among whites. Conclusions: We found race/ethnic differences in the association between age and arterial stiffness and diameter, including age-dependent arterial dilation observed in Hispanics that was not observed among blacks or whites.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalAtherosclerosis
Volume219
Issue number2
DOIs
StatePublished - Dec 1 2011

Fingerprint

Carotid Arteries
Hispanic Americans
Vascular Stiffness
Linear Models
Cerebrovascular Disorders
Ethnic Groups
Coronary Artery Disease
Dilatation
Hypertension
Kidney
Population

Keywords

  • Arterial stiffness
  • Atherosclerosis
  • Carotid artery
  • Carotid ultrasound
  • Diastolic diameter
  • Race/ethnicity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ethnic differences in carotid artery diameter and stiffness : The Northern Manhattan Study. / Markert, Matthew S.; Della Morte, David; Cabral, Digna; Roberts, Eugene L; Gardener, Hannah; Dong, Chuanhui; Wright, Clinton B; Elkind, Mitchell S V; Sacco, Ralph L; Rundek, Tatjana.

In: Atherosclerosis, Vol. 219, No. 2, 01.12.2011, p. 827-832.

Research output: Contribution to journalArticle

Markert, Matthew S. ; Della Morte, David ; Cabral, Digna ; Roberts, Eugene L ; Gardener, Hannah ; Dong, Chuanhui ; Wright, Clinton B ; Elkind, Mitchell S V ; Sacco, Ralph L ; Rundek, Tatjana. / Ethnic differences in carotid artery diameter and stiffness : The Northern Manhattan Study. In: Atherosclerosis. 2011 ; Vol. 219, No. 2. pp. 827-832.
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AU - Markert, Matthew S.

AU - Della Morte, David

AU - Cabral, Digna

AU - Roberts, Eugene L

AU - Gardener, Hannah

AU - Dong, Chuanhui

AU - Wright, Clinton B

AU - Elkind, Mitchell S V

AU - Sacco, Ralph L

AU - Rundek, Tatjana

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N2 - Objective: Race/ethnic differences in carotid arterial function and structure exist among those with cerebrovascular disease, but whether differences persist among healthy populations is unknown. Our objective was to investigate differences in carotid artery diameter and stiffness between race/ethnic groups, and examine whether these race/ethnic differences were age-dependent. Methods: Carotid diameters were assessed by B-mode ultrasound among 1536 participants from the Northern Manhattan Study (NOMAS), and carotid stiffness metrics were calculated. We used multivariable linear regression models to determine the relationship between race/ethnicity and both carotid arterial stiffness and carotid diastolic diameter. Results: Mean participant age was 70 ± 9 years (Hispanics = 68 ± 8, blacks = 72 ± 9, and whites = 74 ± 9, p< 0.0001). Mean DDIAM was 6.2 ± 1.0. mm (Hispanics = 6.2 ± 0.9 mm, blacks = 6.3 ± 1.0. mm, and whites = 6.3 ± 1.0. mm, p< 0.005) and mean STIFF was 8.7 ± 6.3 (Hispanics = 8.5 ± 5.7, blacks = 9.2 ± 6.2 and whites = 8.9 ± 6.9, p< 0.02). In a model that adjusted for sociodemographics and vascular risk factors including hypertension, diabetes, dislipidemia, renal function, physical acticity and a history of known coronary artery diseases; age was positively associated with greater DDIAM in Hispanics (p< 0.0001) but not among blacks or whites. Older age was associated with greater stiffness among Hispanics (p< 0.0001) and blacks (p< 0.003), but not among whites. Conclusions: We found race/ethnic differences in the association between age and arterial stiffness and diameter, including age-dependent arterial dilation observed in Hispanics that was not observed among blacks or whites.

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