Abstract
Background & Aims: Severe obesity is a risk factor for nonalcoholic steatohepatitis (NASH), particularly among ethnic minority groups. The aim of this analysis was to evaluate ethnic group differences in the prevalence of NASH in a large multiethnic sample of bariatric patients not previously well-described in the literature. Methods: A cross-sectional retrospective analysis of 611 liver biopsies among patients, who underwent bariatric surgery from 2001 to 2010, from one bariatric surgery practice in South Florida was conducted. Logistic regression analysis predicted the ethnic group-specific odds of having NASH. Results: Hispanics (43%) and non-Hispanic whites (NHW) (46%) were significantly more likely than non-Hispanic blacks (NHB) (21%) to have advanced steatosis (p = 0.002). Conversely, NHB were significantly more likely to have mild or moderate steatosis (48%) versus both NHW (34%) and Hispanics (36%). Women were over two and a half times as likely as men to have NASH (OR 2.66, 95% CI 1.68-4.24). NHB were almost twice as likely as NHW to have NASH (OR 1.86, 95% CI 1.17-2.94). Conclusions: The prevalence of NASH varies significantly by ethnicity and gender among bariatric surgery patients. These findings have important clinical implications for postoperative health maintenance as NASH carries a risk of progressive liver disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-157 |
| Number of pages | 5 |
| Journal | Bariatric Surgical Practice and Patient Care |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2016 |
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Keywords
- bariatric surgery
- ethnicity
- gender
- nonalcoholic fatty liver disease
- nonalcoholic steatohepatitis
ASJC Scopus subject areas
- Surgery
- Nutrition and Dietetics
- Medical–Surgical
Cite this
Ethnic and Gender Differences in the Prevalence of Nonalcoholic Steatohepatitis among Bariatric Surgery Patients. / Messiah, Sarah; Vidot, Denise; Bispo, Jordan Baeker; Arheart, Kristopher; Khorgami, Zhamak; de la Cruz-Munoz, Nestor.
In: Bariatric Surgical Practice and Patient Care, Vol. 11, No. 4, 01.12.2016, p. 153-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ethnic and Gender Differences in the Prevalence of Nonalcoholic Steatohepatitis among Bariatric Surgery Patients
AU - Messiah, Sarah
AU - Vidot, Denise
AU - Bispo, Jordan Baeker
AU - Arheart, Kristopher
AU - Khorgami, Zhamak
AU - de la Cruz-Munoz, Nestor
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background & Aims: Severe obesity is a risk factor for nonalcoholic steatohepatitis (NASH), particularly among ethnic minority groups. The aim of this analysis was to evaluate ethnic group differences in the prevalence of NASH in a large multiethnic sample of bariatric patients not previously well-described in the literature. Methods: A cross-sectional retrospective analysis of 611 liver biopsies among patients, who underwent bariatric surgery from 2001 to 2010, from one bariatric surgery practice in South Florida was conducted. Logistic regression analysis predicted the ethnic group-specific odds of having NASH. Results: Hispanics (43%) and non-Hispanic whites (NHW) (46%) were significantly more likely than non-Hispanic blacks (NHB) (21%) to have advanced steatosis (p = 0.002). Conversely, NHB were significantly more likely to have mild or moderate steatosis (48%) versus both NHW (34%) and Hispanics (36%). Women were over two and a half times as likely as men to have NASH (OR 2.66, 95% CI 1.68-4.24). NHB were almost twice as likely as NHW to have NASH (OR 1.86, 95% CI 1.17-2.94). Conclusions: The prevalence of NASH varies significantly by ethnicity and gender among bariatric surgery patients. These findings have important clinical implications for postoperative health maintenance as NASH carries a risk of progressive liver disease.
AB - Background & Aims: Severe obesity is a risk factor for nonalcoholic steatohepatitis (NASH), particularly among ethnic minority groups. The aim of this analysis was to evaluate ethnic group differences in the prevalence of NASH in a large multiethnic sample of bariatric patients not previously well-described in the literature. Methods: A cross-sectional retrospective analysis of 611 liver biopsies among patients, who underwent bariatric surgery from 2001 to 2010, from one bariatric surgery practice in South Florida was conducted. Logistic regression analysis predicted the ethnic group-specific odds of having NASH. Results: Hispanics (43%) and non-Hispanic whites (NHW) (46%) were significantly more likely than non-Hispanic blacks (NHB) (21%) to have advanced steatosis (p = 0.002). Conversely, NHB were significantly more likely to have mild or moderate steatosis (48%) versus both NHW (34%) and Hispanics (36%). Women were over two and a half times as likely as men to have NASH (OR 2.66, 95% CI 1.68-4.24). NHB were almost twice as likely as NHW to have NASH (OR 1.86, 95% CI 1.17-2.94). Conclusions: The prevalence of NASH varies significantly by ethnicity and gender among bariatric surgery patients. These findings have important clinical implications for postoperative health maintenance as NASH carries a risk of progressive liver disease.
KW - bariatric surgery
KW - ethnicity
KW - gender
KW - nonalcoholic fatty liver disease
KW - nonalcoholic steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=85006049750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006049750&partnerID=8YFLogxK
U2 - 10.1089/bari.2016.0018
DO - 10.1089/bari.2016.0018
M3 - Article
AN - SCOPUS:85006049750
VL - 11
SP - 153
EP - 157
JO - Bariatric Surgical Patient Care
JF - Bariatric Surgical Patient Care
SN - 2168-023X
IS - 4
ER -