Ethanol injection for the treatment of hepatic tumours

C. Bartolozzi, Riccardo Lencioni

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Percutaneous ethanol injection (PEI) is a relatively new therapeutic technique for the treatment of liver tumours. PEI is now considered a reliable alternative to surgical resection for cirrhotic patients with a single, small hepatocellular carcinoma (HCC). Intratumoral injection of absolute ethanol, in fact, achieves complete ablation of HCC nodules 3 cm or less in diameter with a high probability. Moreover, PEI is not associated with significant morbidity or mortality and does not damage non-cancerous liver parenchyma. Long-term survival rates of PEI-treated patients were similar to those obtained in matched patients submitted to partial hepatectomy. In large HCC lesions, the anticancer effect of PEI can be significantly enhanced by pretreatment of the tumour with transcatheter arterial chemoembolisation. PEI may also be effectively used to destroy adenomatous hyperplastic nodules in liver cirrhosis, which represent precancerous lesions. The results of PEI in the treatment of liver metastases, in contrast, have been far less encouraging than in the case of HCC, so that PEI is not recommended when other interventional procedures such as radiofrequency electrocautery or interstitial laser photocoagulation are available. Imaging procedures plays a key role in PEI, as they provide a reliable assessment of the therapeutic effect of the procedure.

Original languageEnglish (US)
Pages (from-to)682-696
Number of pages15
JournalEuropean Radiology
Volume6
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Ethanol
Injections
Liver
Neoplasms
Hepatocellular Carcinoma
Therapeutics
Electrocoagulation
Light Coagulation
Hepatectomy
Therapeutic Uses
Liver Cirrhosis
Lasers
Survival Rate
Neoplasm Metastasis
Morbidity
Mortality

Keywords

  • Alcohol
  • Liver neoplasms, diagnosis
  • Liver neoplasms, therapy
  • Liver, interventional procedure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Bartolozzi, C., & Lencioni, R. (1996). Ethanol injection for the treatment of hepatic tumours. European Radiology, 6(5), 682-696.

Ethanol injection for the treatment of hepatic tumours. / Bartolozzi, C.; Lencioni, Riccardo.

In: European Radiology, Vol. 6, No. 5, 1996, p. 682-696.

Research output: Contribution to journalArticle

Bartolozzi, C & Lencioni, R 1996, 'Ethanol injection for the treatment of hepatic tumours', European Radiology, vol. 6, no. 5, pp. 682-696.
Bartolozzi C, Lencioni R. Ethanol injection for the treatment of hepatic tumours. European Radiology. 1996;6(5):682-696.
Bartolozzi, C. ; Lencioni, Riccardo. / Ethanol injection for the treatment of hepatic tumours. In: European Radiology. 1996 ; Vol. 6, No. 5. pp. 682-696.
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