Estrogens and the hair follicle

Franziska Conrad, Ralf Paus

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

While it is undisputed that estrogens (17β-stradiol, E2) are mainly involved in skin physiology and operate as potent hair growth modulators, our knowledge about the estrogen target cells in skin and exact signaling pathways is still very limited. The current review provides an overview of estrogen effects on hair follicle cycling, cutaneous expression of estrogen receptors, and potential functions of estrogens in hair biology. We discuss potential target genes of estrogen receptor-mediated signaling in the skin, explore the interplay of estrogens with other hormones, growth factors and enzymes, and define major open questions in this intriguing and far too long neglected area of hair research.

Original languageEnglish (US)
Pages (from-to)412-423
Number of pages12
JournalJDDG - Journal of the German Society of Dermatology
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Hair Follicle
Estrogens
Hair
Estrogen Receptors
Skin
Skin Physiological Phenomena
Intercellular Signaling Peptides and Proteins
Hormones
Enzymes
Growth
Research
Genes

Keywords

  • 17β-estradiol
  • Estrogen receptor-α,-β
  • Hair follicle cycling
  • Hair growth
  • Ligand-inducible transcription factors
  • Steroid hormones

ASJC Scopus subject areas

  • Dermatology

Cite this

Estrogens and the hair follicle. / Conrad, Franziska; Paus, Ralf.

In: JDDG - Journal of the German Society of Dermatology, Vol. 2, No. 6, 01.06.2004, p. 412-423.

Research output: Contribution to journalReview article

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